Revolution Stalled
Revolution Stalled
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DOI：
10.1126/scitranslmed.3003142
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发表时间：
2012-10-10
影响因子：
17.1
通讯作者：
Hyman, Steven E.
中科院分区：
文献类型：
--
作者：
Hyman, Steven E.
治疗精神疾病（如精神分裂症、双相情感障碍、抑郁症和常见形式的自闭症）的药物发现几乎处于停滞状态。尽管精神病学发病率高，医疗需求未得到满足，但各大制药公司正在淡化或退出精神病学，从而大大削弱了发现新药的能力。在这篇评论中，我从科学的角度阐述了问题所在，并提出了如何解决这一危险局面的问题。
Drug discovery is at a near standstill for treating psychiatric disorders such as schizophrenia, bipolar disorder, depression, and common forms of autism. Despite high prevalence and unmet medical need, major pharmaceutical companies are deemphasizing or exiting psychiatry, thus removing significant capacity from efforts to discover new medicines. In this Commentary, I develop a view of what has gone wrong scientifically and ask what can be done to address this parlous situation.