Back Cover: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. Int. Ed. 14/2017)
Back Cover: Selected Mutations Reveal New Intermediates in the Biosynthesis of Mupirocin and the Thiomarinol Antibiotics (Angew. Chem. Int. Ed. 14/2017)
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封底：选定的突变揭示了莫匹罗星和硫代马林醇抗生素生物合成中的新中间体（Angew. Chem. Int. Ed. 14/2017）
DOI：
10.1002/anie.201702123
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Gao S
中科院分区：
文献类型：
--
作者：
Gao S
.反直觉的生物合成中间体假单胞菌酸B转化为假单胞菌酸A，这对应于羟基的形式损失，需要实现其全部抗生素潜力。在他们的来文中，第3930页及以后，TJ Simpson、CL Willis及其同事描述了参与这种转化的中间体的完整序列，并通过基因敲除和互补实验鉴定了相关基因。
. The conversion…… of the counterintuitive biosynthetic intermediate pseudomonic acid B into pseudomonic acid A, which corresponds to the formal loss of a hydroxy group, is required to realize its full antibiotic potential. In their Communication on page3930 ff., TJ Simpson, CL Willis, and co-workers describe the full sequence of intermediates involved in this conversion and the identification of the associated genes by gene knockout and complementation experiments.