Diffusion-weighted imaging of inflammatory myopathies: Polymyositis and dermatomyositis
Diffusion-weighted imaging of inflammatory myopathies: Polymyositis and dermatomyositis
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DOI：
10.1002/jmri.21209
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发表时间：
2008-01-01
影响因子：
4.4
通讯作者：
Park, Jane H.
中科院分区：
文献类型：
--
作者：
Qi, Jing;Olsen, Nancy J.;Park, Jane H.
用MRI检查的肌炎患者的肌肉表现出从未受影响的肌肉群到严重炎症、脂肪浸润以及最终更严重的脂肪替代的异质性病理。本研究的目的是使用弥散加权成像（DWI）来表征肌炎性大腿克莱斯，并检查不同疾病阶段的流体运动。我们选择使用Le Bihan等人[6，7]提出的模型来表征肌肉内的总流体运动，其中确定了表观扩散系数（ADC）、细胞外和细胞内肌肉隔室中的扩散（D）、毛细血管中的灌注（假扩散）（D*）和毛细血管灌注的体积分数（f）。未受影响的患者肌肉的DWI系数与正常肌肉的DWI系数相等。与正常肌肉相比，发炎肌肉显示出升高的ADC和D值（P < 0.0005），并且脂肪浸润的肌肉具有低于对照肌肉的值（P < 0.001）。炎症肌肉的f值低于未受影响的肌肉（P < 0.009），表明毛细血管灌注分数体积降低。DWI提供了病变肌肉中分子流体运动的定量数据，并为肌炎患者的纵向监测提供了可能。
Muscles of myositis patients examined with MRI demonstrate heterogeneous pathology ranging from unaffected muscle groups to severe inflammation, fat infiltration, and eventually, more serious fat replacement. The purpose of this investigation was to characterize myositic thigh mus cles using diffusion-weighted imaging (DWI) and to examine fluid motion at various disease stages. We chose to characterize total fluid motion within the muscle using the model proposed by Le Bihan et a] (6,7) in which the apparent diffusion coefficient (ADC), diffusion in the extra- and intracellular muscle compartments (D), perfusion in capillaries (pseudodiffusion) (D*), and volume fraction of capillary perfusion (f) are determined. Unaffected patient muscles have DWI coefficients equivalent to those of normal muscles. Inflamed muscles show elevated ADC and D values compared to normal muscles (P < 0.0005), and fat-infiltrated muscles have lower values than control muscles (P < 0.001). Inflamed muscles have lower f values than unaffected muscles (P < 0.009), suggesting decreased fractional volume of capillary perfusion. DWI provides quantitative data on molecular fluid motion in diseased muscles and affords the potential for longitudinal monitoring of myositic patients.