Droplet-on-a-wristband: Chip-to-chip digital microfluidic interfaces between replaceable and flexible electrowetting modules
Droplet-on-a-wristband: Chip-to-chip digital microfluidic interfaces between replaceable and flexible electrowetting modules
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DOI：
10.1039/c01c00178c
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发表时间：
2011-01-01
期刊：
影响因子：
6.1
通讯作者：
Hsu, Wensyang
中科院分区：
文献类型：
--
作者：
Fan, Shih-Kang;Yang, Hanping;Hsu, Wensyang
我们提出了一个长（204 mm），弯曲（曲率为0.04 mm（-1）），并在“腕带上的液滴”（DOW）与设计的数字微流体模块化接口的电信号和液滴连接的基础上的电润湿介质（EWOD）在倾斜和弯曲的设备的研究封闭的液滴路径。代替使用密封和防漏管道来传输液体和泵送压力，所展示的用于电润湿驱动的数字微流体的模块化接口在两个相邻的平行板模块之间提供简单的电气和流体连接，这些模块易于连接/分离，显示出使用微滴用于模块之间的微流体连接的优点。利用先前报道的数字-通道接口（Abdelgawad等人，Lab Chip，2009，9，1046-1051），这里提出的芯片到芯片接口将进一步应用于连续微流体。研究了液滴在单个顶板间隙和两个重叠板之间间隙的模块化接口中的泵送情况。为了确保DOW中的液滴输送，我们在通过特殊刀片切割机和低温工艺制备的柔性PET基板上制造的倾斜或弯曲设备中对抗重力驱动液滴。通过沿着由4英寸晶片设备制造的DOW的四个柔性模块顺序切换全部136个驱动电极（1.5 mm × 1.5 mm），实现了以高于105 mm s（-1）的速度泵送2.5 μ l液滴。
We present a long (204 mm), curved (curvature of 0.04 mm(-1)), and closed droplet pathway in "droplet-on-a-wristband" (DOW) with the designed digital microfluidic modular interfaces for electric signal and droplet connections based on the study of electrowetting-on-dielectric (EWOD) in inclined and curved devices. Instead of using sealed and leakage-proof pipes to transmit liquid and pumping pressure, the demonstrated modular interface for electrowetting-driven digital microfluidics provides simply electric and fluidic connections between two adjacent parallel-plate modules which are easy-to-attach/detach, showing the advantages of using droplets for microfluidic connections between modules. With the previously reported digital-to-channel interfaces (Abdelgawad et al., Lab Chip, 2009, 9, 1046-1051), the chip-to-chip interface presented here would be further applied to continuous microfluidics. Droplet pumping across a single top plate gap and through a modular interface with two gaps between overlapping plates are investigated. To ensure the droplet transportation in the DOW, we actuate droplets against gravity in an inclined or curved device fabricated on flexible PET substrates prepared by a special razor blade cutter and low temperature processes. Pumping a 2.5 mu l droplet at a speed above 105 mm s(-1) is achieved by sequentially switching the entire 136 driving electrodes (1.5 mm x 1.5 mm) along the four flexible modules of the DOW fabricated by 4-inch wafer facilities.