Impact of diabetes on cognitive function and brain structure.
Impact of diabetes on cognitive function and brain structure.
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DOI：
10.1111/nyas.12807
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发表时间：
2015-09
影响因子：
5.2
通讯作者：
Seaquist ER
中科院分区：
文献类型：
--
作者：
Moheet A;Mangia S;Seaquist ER
1型和2型糖尿病都与认知功能多个领域的表现降低以及大脑结构异常有关。随着人口老龄化和糖尿病流行的日益增长，预计糖尿病的中枢神经系统相关并发症将增加，并可能对未来的公共卫生产生挑战性影响。在这篇综述中，我们将讨论与1型和2型糖尿病相关的脑结构和功能变化。糖尿病病程和血糖控制可能在糖尿病认知障碍的发展中起重要作用，但引起这些认知和结构变化的确切潜在病理生理机制尚不清楚。未来的研究需要更好地了解自然史和潜在机制，以及确定预测谁最有可能发展认知障碍的风险因素。这些信息将导致新的策略的发展，以尽量减少糖尿病对认知功能的影响。
Both type 1 and type 2 diabetes have been associated with reduced performance on multiple domains of cognitive function and with structural abnormalities in the brain. With an aging population and a growing epidemic of diabetes, central nervous system–related complications of diabetes are expected to rise and could have challenging future public health implications. In this review, we will discuss the brain structural and functional changes that have been associated with type 1 and type 2 diabetes. Diabetes duration and glycemic control may play important roles in the development of cognitive impairment in diabetes, but the exact underlying pathophysiological mechanisms causing these changes in cognition and structure are not well understood. Future research is needed to better understand the natural history and the underlying mechanisms, as well as to identify risk factors that predict who is at greatest risk of developing cognitive impairment. This information will lead to the development of new strategies to minimize the impact of diabetes on cognitive function.