Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis
Prevalence and Risk Factors for Osteopathy in Chronic Pancreatitis
复制标题
慢性胰腺炎骨病的患病率和危险因素
DOI：
10.1007/s10620-020-06732-2
复制
发表时间：
2021
影响因子：
3.1
通讯作者：
Liao Zhuan
中科院分区：
文献类型：
--
作者：
Tang Xin-Ying;Ru Nan;Li Qing;Qian Yang-Yang;Sun Hui;Zhu Jia-Hui;He Lin;Wang Yuan-Chen;Hu Liang-Hao;Li Zhao-Shen;Zou Wen-Bin;Liao Zhuan
背景和目的近年来，慢性胰腺炎（CP）患者骨病的高发病率引起了越来越多的关注。本研究的目的是评估中国脑瘫患者骨病的患病率和危险因素。方法这是一项针对中国大型中心脑瘫患者的横断面研究；患者于2017年1月31日至2018年1月31日期间招募。对骨密度和实验室测试（包括骨相关生化、炎症和激素参数）进行前瞻性评估。分析了患有骨病和未患有骨病的患者之间的差异。使用逻辑回归分析来研究变量之间的关联。结果总共有 104 名 CP 患者纳入本研究（68.3% 为特发性，31.7% 为酒精性）。根据M-ANNHEIM分类，87.5%的患者处于早期阶段（0-II）。 30.8% 的患者被诊断为骨质减少症，5.8% 的患者被诊断为骨质疏松症；因此，共有 36.5% 的患者出现骨病。多因素分析显示，CP患者发生骨病的独立危险因素为年龄（OR = 1.04；95% CI = 1.00–1.08；P= 0.030）、BMI（OR = 0.72；95% CI = 0.58–0.89；P= 0.003）和PTH（OR = 0.96；95% CI = 0.93–1.00；P= 0.022）。结论本研究首次报告了中国CP患者骨病的患病率。研究发现，年龄和低体重指数是骨病的重要危险因素。低 PTH（但在正常范围内）与骨病的关联较弱，值得进一步探索。
Background and AimsThe high incidence of osteopathy among patients with chronic pancreatitis (CP) has garnered increased attention over recent years. The aims of this study were to assess the prevalence and risk factors for osteopathy in Chinese patients with CP.MethodsThis was a cross-sectional study of CP patients from a large center in China; patients were recruited between 31 January 2017 and 31 January 2018. Bone density and laboratory tests, including bone-related biochemical, inflammatory, and hormone parameters, were assessed prospectively. Differences between patients with and without osteopathy were analyzed. Logistic regression analysis was used to investigate associations between variables.ResultsIn total, 104 CP patients were enrolled in this study (68.3% idiopathic and 31.7% alcoholic). According to the M-ANNHEIM classification, 87.5% of the patients were at an early stage (0–II). Osteopenia was diagnosed in 30.8% of patients and osteoporosis in 5.8%; thus, a total of 36.5% of patients presented with osteopathy. In multivariate analysis, the independent risk factors for osteopathy in CP patients were age (OR = 1.04; 95% CI = 1.00–1.08;P= 0.030), BMI (OR = 0.72; 95% CI = 0.58–0.89;P= 0.003), and PTH (OR = 0.96; 95% CI = 0.93–1.00;P= 0.022).ConclusionsThis study is the first to report the prevalence of osteopathy in Chinese patients with CP. It found that age and low BMI are significant risk factors for osteopathy. Low PTH (but within the normal range) showed a weak association with osteopathy, which warrants further exploration.