Fusiform micelles from nonlinear poly(ethylene glycol)/polylactide copolymers as biodegradable drug carriers.
Fusiform micelles from nonlinear poly(ethylene glycol)/polylactide copolymers as biodegradable drug carriers.
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DOI：
10.1002/mabi.201100147
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发表时间：
2011-11
影响因子：
4.6
通讯作者：
Taihang Li;Ruiyan Han;Mingzhe Wang;Changbai Liu;X. Jing;Yubin Huang
中科院分区：
文献类型：
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作者：
Taihang Li;Ruiyan Han;Mingzhe Wang;Changbai Liu;X. Jing;Yubin Huang
制备了具有哑铃型和Y型结构的PEG-PLA共聚物。它们在水溶液中可以从纳米粒子自组装成微米级的梭形胶束粒子。特别地，由（PLA）2-PEG-（PLA）2颗粒形成的胶束显示出比由线性MPEG-PLA形成的胶束更好的药物负载能力和包封效率。体外研究表明，由Y形共聚物形成的颗粒显示出特别快速的药物释放。该共聚物具有良好的生物相容性和低细胞毒性。因此，这些独特的自组装系统具有许多可能的生物医学应用，例如高剂量水不溶性药物的持续递送、创伤的快速有效药物、口服给药药物的受控递送等。
PEG-PLA copolymers with dumbbell- and Y-shaped structures are prepared. They can self-assemble from nanoparticles to micro-sized fusiform micellar particles in aqueous solution. In particular the micelles formed by the (PLA)2-PEG-(PLA)2 particles show a better drug loading capacity and encapsulation efficiency than those formed by linear MPEG-PLA. In vitro studies show that the particles formed by Y-shaped copolymers show a particularly quick drug release. The copolymers have good biocompatibility with low cytotoxicity. These unique self-assembled systems thus have many possible biomedical applications, such as a sustained delivery of high-dosed water insoluble drugs, quick effective drugs for trauma, controlled delivery of the oral-administration drugs, and so forth.