Cortical responsiveness during talking and listening in schizophrenia: An event-related brain potential study
Cortical responsiveness during talking and listening in schizophrenia: An event-related brain potential study
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DOI：
10.1016/s0006-3223(01)01166-0
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发表时间：
2001-10-01
影响因子：
10.6
通讯作者：
Roth, WT
中科院分区：
文献类型：
--
作者：
Ford, JM;Mathalon, DH;Roth, WT
背景：无法识别自我产生的内心语言可能是精神分裂症样幻听的阳性症状的基础。这可能是由于听觉皮层在与语言相关的推论放电和思考或说话时的参照放电之间进行了错误的比较，错误地将内部思想归因于外部来源。虽然很有说服力，但对隐蔽言论（思想）的监控失败并不像对公开言论（谈话）的监控失败那样容易被调查。方法：以10名健康成人和12名精神分裂症患者（DSM-IV）为研究对象，在大声说话、听录音和沉默基线时，采用N1事件相关电位（ERPs）对听觉皮层反应性的影响进行评估。被谈话时肌肉伪影污染的试验被排除在外。结果：说话和听力对声学探针N1有影响，而对视觉探针N1无影响，反映了影响的模态特异性。对声探针的反应模式在对照组和患者之间有所不同。与基线相比，对照组受试者说话时声探针的N1降低，但患者没有。在两组中，听力同样降低了NI。结论：虽然谈话过程中N1不能降低与患者当前的幻觉无关，但可能与患者产生幻觉的可能性有关。中华医学会精神病学分会，2001,19(3)。
Background: Failures to recognize inner speech as self-generated may underlie positive symptoms of schizophrenia-like auditory hallucinations. This could result from a faulty comparison in auditory cortex between speech-related corollary discharge and reafferent discharges from thinking or speaking, with misattribution of internal thoughts to external sources. Although compelling, failures to monitor covert speech (thoughts) are not as amenable to investigation as failures to monitor overt speech (talking).Methods: Effects of talking on auditory cortex responsiveness were assessed in 10 healthy adults and 12 patients with schizophrenia (DSM-IV) using N1 event-related potentials (ERPs) to acoustic and visual probes during talking aloud, listening to one's speech played back, and silent baseline. Trials contaminated by muscle artifact while talking were excluded.Results: Talking and listening affected N1 to acoustic but not to visual probes, reflecting modality specificity of effects. Patterns of responses to acoustic probes differed between control subjects and patients. N1 to acoustic probes was reduced during talking compared with baseline in control subjects, but not in patients. Listening reduced NI equivalently in both groups.Conclusions: Although the failure of N1 to be reduced during talking was not related to current hallucinations in patients, it may be related to the potential to hallucinate. Biol Psychiatry 2001:50:540-549 (C) 2001 Society of Biological Psychiatry.