Obesity and weight gain in adulthood and telomere length.
Obesity and weight gain in adulthood and telomere length.
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DOI：
10.1158/1055-9965.epi-08-0935
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发表时间：
2009-03
期刊：
影响因子：
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通讯作者：
Sandler DP
中科院分区：
文献类型：
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作者：
Kim S;Parks CG;DeRoo LA;Chen H;Taylor JA;Cawthon RM;Sandler DP
成年期的肥胖和体重增加与几种癌症的风险增加有关。端粒在维持基因组完整性方面起着关键作用，并可能参与癌的发生。使用来自美国和波多黎各（2003-4）的647名年龄在35-74岁的女性的数据，我们研究了当前和过去的人体测量特征与血细胞端粒长度之间的关联。在多元线性回归模型中，较高的当前体重指数（BMI）和臀围与端粒长度呈负相关。在40岁或以上的女性中，30多岁时较高的BMI与较短的端粒长度相关（趋势p < 0.01）。自30岁以来的体重增加（趋势p = 0.07）和体重循环（趋势p = 0.04）也与端粒长度呈负相关。当将当前BMI和30-39岁时的BMI放在一起考虑时，发现在两个时间点都有超重或肥胖BMI的女性（平均T/S比=1.26，95%CI：1.21-1.30）与在两个时间点都有正常BMI的女性（平均T/S比= 1.33，95%CI：1.30-1.36）相比，端粒长度的减少最明显。这些发现支持了肥胖可能加速衰老的假设，并强调了成年后保持理想体重的重要性。
Obesity and weight gain in adulthood are associated with an increased risk of several cancers. Telomeres play a critical role in maintaining genomic integrity, and may be involved in carcinogenesis. Using data from 647 women aged 35–74 in the U.S. and Puerto Rico (2003-4), we examined the association between current and past anthropometric characteristics and telomere length in blood cells. In a multivariate linear regression model, higher current body mass index (BMI) and hip circumference were inversely associated with telomere length. Higher BMI in the 30s was associated with shorter telomere length among women aged 40 years or older (p for trend < 0.01). Weight gain since age 30s (p for trend = 0.07) and weight cycling (p for trend = 0.04) were also inversely associated with telomere length. When current BMI and BMI at ages 30–39 were considered together, the most marked decrease in telomere length was found for women who had overweight or obese BMI at both time points (mean T/S ratio=1.26, 95% CI: 1.21–1.30) compared with women who had normal BMI at both times (mean T/S ratio = 1.33, 95% CI: 1.30–1.36). These findings support the hypothesis that obesity may accelerate aging, and highlight the importance of maintaining a desirable weight in adulthood.