Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression
Assessing the Risk Factors for Difficult-to-Treat Depression and Treatment-Resistant Depression
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DOI：
10.4088/jcp.14077su1c.01
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发表时间：
2016-01-01
影响因子：
5.3
通讯作者：
Gaynes, Bradley
中科院分区：
文献类型：
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作者：
Gaynes, Bradley
根据世界卫生组织的数据，抑郁症是全球人口残疾的主要原因。在确诊的患者中，许多人在遵循推荐的抗抑郁药物和心理社会治疗后未能获得缓解。特别是，难治性抑郁症和难治性抑郁症可能会对患者造成严重损害，包括认知功能减弱、医疗账单增加、工作场所表现下降，以及患合并症的风险增加。然而，临床医生可以使用许多工具来识别难治性抑郁症，包括9个问题的患者健康问卷(PHQ-9)和抑郁症状学快速清单(QDS-SR16)等评分表，以及与难治性或难治性抑郁症风险因素相关的临床证据。准确识别难治性抑郁症是改变治疗方案以帮助患者缓解的第一步。
Depression is the leading cause of disability among people across the globe, according to the World Health Organization. Among those who have been diagnosed, many fail to achieve remission after following recommended antidepressant medication and psychosocial therapies. In particular, difficult-to-treat and treatment-resistant depression may cause severe impairments for patients, including diminished cognitive functioning, increased medical bills, and decreased workplace performance, as well as an increased risk of developing comorbid illnesses. However, many tools are available to clinicians for identifying treatment-resistant depression, including rating scales such as the 9-question Patient Health Questionnaire (PHQ-9) and the Quick Inventory of Depressive Symptomatology (QIDS-SR16), as well as clinical evidence related to risk factors for difficult-to-treat or treatment-resistant depression. Accurately identifying treatment-resistant depression is the first step toward changing treatment regimens to help patients achieve remission.