ASSOCIATION OF HLA-DPB1-ASTERISK-0501 WITH EARLY-ONSET GRAVES-DISEASE IN JAPANESE
ASSOCIATION OF HLA-DPB1-ASTERISK-0501 WITH EARLY-ONSET GRAVES-DISEASE IN JAPANESE
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DOI：
10.1016/0198-8859(94)90260-7
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发表时间：
1994-03-01
期刊：
影响因子：
2.7
通讯作者：
INOKO, H
中科院分区：
文献类型：
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作者：
ONUMA, H;OTA, M;INOKO, H
为了研究日本人Graves病与HLA抗原之间的关系，采用PCR-RFLP方法进行了血清学分型和DPB 1基因分型。本文对106例Graves病患者进行了HLA等位基因检测，发现HLA-B_（46）基因频率明显增高。此外，两个年龄组之间的HLA抗原的频率进行了比较：早发性和晚发性患者（20岁以下和20岁以上，分别）。发现早发组DPB 1 * 0501的频率（88.9%）显著高于健康对照组（55.0%）（p（c）<0.004），而晚发组DPB 1 * 0501的频率（60.7%）则无显著差异。另一方面，在晚发型患者中观察到HLA-B46的显著增加（p（c）<0.0004）。这些结果表明，日本早发性Graves病患者的遗传背景与晚发性患者不同。即，HLA-DP等位基因（DPB 1 * 0501）和HLA-B等位基因（B46）分别主要参与日本人早发性和晚发性Graves病的发病机制。
To investigate the association between HLA antigens and Graves' disease among Japanese, serologic typing and DPB1 genotyping using the PCR-RFLP method have been performed. HLA alleles of 106 patients with Graves' disease were determined, and the frequency of HLA-B46 was found to be significantly increased. Furthermore, the frequencies of HLA antigens were compared between two age groups: early-onset and late-onset patients (under and over 20 years, respectively). It was found that the frequency of DPB1*0501 (88.9%) was significantly increased (p(c) < 0.004) in the early-onset group as compared with the healthy controls (55.0%) but not in the late-onset group (60.7%). On the other hand, a significant increase of HLA-B46 was observed in the late-onset patients (p(c) < 0.0004). These results suggest that the genetic background of Japanese patients with early-onset Graves' disease is different from late-onset patients. Namely, the HLA-DP allele (DPB1*0501) and the HLA-B allele (B46) are primarily involved in the pathogenesis of early-onset and late-onset Graves' disease in Japanese, respectively.