Differential regulation of cardiac expression of IL-6 and TNF-alpha by A2- and A3-adenosine receptors.
Differential regulation of cardiac expression of IL-6 and TNF-alpha by A2- and A3-adenosine receptors.
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A2- 和 A3- 腺苷受体对心脏 IL-6 和 TNF-α 表达的差异调节。
DOI：
10.1152/ajpheart.1999.276.6.h2141
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发表时间：
1999
期刊：
影响因子：
--
通讯作者：
Feldman,AM
中科院分区：
文献类型：
--
作者：
Wagner,DR;Kubota,T;Sanders,VJ;McTiernan,CF;Feldman,AM
The proinflammatory cytokines tumor necrosis factor (TNF)-α and interleukin (IL)-6 have been implicated in the development of congestive heart failure. Adenosine inhibits the expression of TNF-α and IL-6 in macrophages. We determined the effect of adenosine on cytokine expression in rat cardiomyocytes and trabecular muscles obtained from patients with cardiomyopathy. In myocytes, adenosine suppressed TNF-α mRNA by 40% (P< 0.05) and induced a 4.7-fold increase in IL-6 mRNA (P< 0.05) with a twofold increase in IL-6 protein release (P< 0.001). The effect on TNF-α could be replicated by A2agonist. The effect on IL-6 could be replicated by A3agonist, but not by A1and A2agonists, and was completely suppressed by A3antagonist. In human trabecular muscles, A2agonist suppressed TNF-α mRNA by 60% (P< 0.05), but adenosine had no effect on IL-6. In the failing heart, IL-6 was immunolocalized to inflammatory cells. Thus A2and A3receptors differentially regulate cardiac expression of TNF-α and IL-6. Rat cardiomyocytes and the failing human heart respond differently to adenosine.
