Kinetic proofreading of gene activation by chromatin remodeling
Kinetic proofreading of gene activation by chromatin remodeling
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DOI：
10.2976/1.2909080
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发表时间：
2008-06-01
期刊：
影响因子：
--
通讯作者：
Schiessel, H.
中科院分区：
文献类型：
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作者：
Blossey, R.;Schiessel, H.
真核生物中的基因激活涉及组蛋白尾部修饰剂、染色质重塑剂和转录因子的协同作用，其精确协调目前尚不清楚。我们证明了实验观察到的分子间相互作用与动力学校正方案是雅阁的。我们的研究结果可以为真核生物中基于染色质修饰剂组合相互作用的基因调控定量模型的建立提供基础。
Gene activation in eukaryotes involves the concerted action of histone tail modifiers, chromatin remodelers, and transcription factors, whose precise coordination is currently unknown. We demonstrate that the experimentally observed interactions of the molecules are in accord with a kinetic proofreading scheme. Our finding could provide a basis for the development of quantitative models for gene regulation in eukaryotes based on the combinatorical interactions of chromatin modifiers.