Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with Clopidogrel in acute coronary syndrome
Effect of cytochrome P450 polymorphisms on platelet reactivity after treatment with Clopidogrel in acute coronary syndrome
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DOI：
10.1016/j.amjcard.2007.11.065
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发表时间：
2008-04-15
影响因子：
2.8
通讯作者：
Alessi, Marie-Christine
中科院分区：
文献类型：
--
作者：
Frere, Corinne;Cuisset, Thomas;Alessi, Marie-Christine
细胞色素P450（CYP）亚型的遗传多态性可能促进血小板对氯吡格雷反应的变异性。本研究分析了603例非ST段抬高型急性冠脉综合征患者的CYP 3A 4、CYP 3A 5和CYP 2C 19基因多态性对氯吡格雷反应和治疗后血小板反应性的影响，这些反应性通过二磷酸腺苷（ADP）诱导的血小板聚集、血管扩张剂刺激的磷蛋白磷酸化指数和ADP诱导的P-选择素表达来评估。CYP 2C 19 *2多态性。与ADP诱导的血小板聚集、血管扩张剂刺激的磷蛋白磷酸化指数和ADP诱导的P-选择素表达呈隐性相关（p
Genetic polymorphisms of cytochrome P450 (CYP) isoforms may promote variability in platelet response to clopidogrel. This study was conducted to analyze, in 603 patients with non-ST elevation acute coronary syndromes, the effect of CYP3A4, CYP3A5, and CYP2C19 gene polymorphisms on clopidogrel response and post-treatment platelet reactivity assessed by adenosine diphosphate (ADP)-induced platelet aggregation, vasodilator-stimulated phosphoprotein phosphorylation index, and ADP-induced P-selectin expression. The CYP2C19*2 polymorphism. was significantly associated with ADP-induced platelet aggregation, vasodilator-stimulated phosphoprotein phosphorylation index, and ADP-induced P-selectin expression in recessive (p