IL-21 mediates suppressive effects via its induction of IL-10.
IL-21 mediates suppressive effects via its induction of IL-10.
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DOI：
10.4049/jimmunol.0802978
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发表时间：
2009-03-01
期刊：
影响因子：
--
通讯作者：
Leonard WJ
中科院分区：
文献类型：
--
作者：
Spolski R;Kim HP;Zhu W;Levy DE;Leonard WJ
IL-21 is a pleiotropic cytokine that is required for normal immunoglobulin production. We previously showed that IL-21 was elevated in BXSB-Yaa mice with systemic lupus erythematosus. These mice also have elevated IL-10 levels, and we now show that IL-21 induces IL-10 mRNA and protein, suggesting unexpected immunosuppressive activities for IL-21. Indeed, Th1 priming with IL-21 leads to accumulation of cells with immunosuppressive activity, and IL-21 over-expression decreases specific antibody production after immunization in an IL-10-dependent fashion. Moreover, we show that IL-21 signaling is required for maximal induction of IL-10 by IL-6 or IL-27. Overall, our data indicate that IL-21 regulates immune responses at least in part by inducing IL-10 and reveal unanticipated immunosuppressive actions for this cytokine.
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