Seroprevalence and risk factors for Toxoplasma gondii infection in domestic cats in The Netherlands
Seroprevalence and risk factors for Toxoplasma gondii infection in domestic cats in The Netherlands
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DOI：
10.1016/j.prevetmed.2012.01.003
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发表时间：
2012-05-01
影响因子：
2.6
通讯作者：
van der Giessen, J. W. B.
中科院分区：
文献类型：
--
作者：
Opsteegh, M.;Haveman, R.;van der Giessen, J. W. B.
猫作为最终宿主，在刚地弓形虫的传播中起着重要作用。为了确定荷兰家猫中弓形虫感染的血清流行率和危险因素，采用间接he法对450只猫的血清样本进行了弓形虫抗体检测。采用二元混合分析估计每只猫的血清阳性率、最佳临界值和阳性概率。血清患病率估计为18.2% (95% CI: 16.6-20.0%)，在幼龄猫中随着年龄的增长而下降，在大约4岁时上升，此后在20%至30%之间。通过多变量logistic回归分析，确定狩猎（OR 4.1）、家中是否有狗（OR 2.1）、曾经流浪猫（OR 3.3）和喂养生肉（OR 2.7）为危险因素。通过对阳性概率的线性回归估计患病率差异，并用于计算每个危险因素的人口归因分数。在抽样人群中，狩猎对弓形虫血清阳性率贡献最大（35%）。(c) 2012 Elsevier B.V.版权所有
Cats, as definitive hosts, play an important role in the transmission of Toxoplasma gondii. To determine the seroprevalence and risk factors for T. gondii infection in Dutch domestic cats, serum samples of 450 cats were tested for T. gondii antibodies by indirect HIM. Binary mixture analysis was used to estimate the seroprevalence, the optimal cut-off value and the probability of being positive for each cat. The seroprevalence was estimated at 18.2% (95% CI: 16.6-20.0%) and showed a decrease with age in very young cats, an increase up to about 4 years old and ranged between 20 and 30% thereafter. Hunting (OR 4.1), presence of a dog in the household (OR 2.1), former stray cat (OR 3.3) and feeding of raw meat (OR 2.7) were identified as risk factors by multivariable logistic regression analysis. Prevalence differences were estimated by linear regression on the probabilities of being positive and used to calculate the population attributable fractions for each risk factor. Hunting contributed most to the T. gondii seroprevalence in the sampled population (35%). (c) 2012 Elsevier B.V. All rights reserved.