The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling
The role of E. coli Nus-factors in transcription regulation and transcription:translation coupling
复制标题
大肠杆菌 Nus-因子在转录调控和转录与翻译耦合中的作用
DOI：
10.4161/trns.2.3.15671
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发表时间：
2011-01-01
影响因子：
3.6
通讯作者：
Rosch, Paul
中科院分区：
文献类型：
--
作者：
Burmann, Bjoern M.;Rosch, Paul
细菌的RNA聚合酶(RNAP)转录是一个高度调控的过程，在细菌的启动、延伸和终止的不同阶段，RNAP的作用都受到蛋白质的调控，如大肠杆菌NUS转录因子等。在这里，我们讨论了直接参与伸长、转录翻译偶联和终止过程的NUS因子的结构相互作用和机制作用，以及这些蛋白质在附加信号影响下对转录的不同影响。
Bacterial transcription mediated by RNA polymerase (RNAP) is a highly regulated process and RNAP action is modulated during the different phases of initiation, elongation and termination by proteins such as the Escherichia coli Nus transcription-factors. Here we discuss the structural interplay and the mechanistic role of the Nus-factors that are directly involved in the processivity of elongation, transcription translation coupling and termination, as well as the varying effects of these proteins on transcription under the influence of additional signals.