Improving preclinical models of HIV microbicide efficacy.
Improving preclinical models of HIV microbicide efficacy.
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DOI：
10.1016/j.tim.2015.05.001
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发表时间：
2015-08
影响因子：
15.9
通讯作者：
Münch J
中科院分区：
文献类型：
--
作者：
Roan NR;Münch J
尽管体外杀菌剂具有强大的体外功效，但大多数外用杀菌剂未能有效预防艾滋病毒传播。临床失败的原因之一可能是目前的杀菌剂测试不能反映性病毒传播过程中遇到的环境。我们讨论如何通过更接近地模仿现实生活条件来改进临床前杀菌剂的开发。
Despite potent in vitro efficacy, most topical microbicides failed to effectively prevent HIV transmission. One reason for clinical failure may be that current microbicide testing does not reflect the environment encountered during sexual virus transmission. We discuss how preclinical microbicide development could be improved by more closely mimicking real-life conditions.