Myofibroblast distribution is associated with invasive growth types of colorectal cancer.
Myofibroblast distribution is associated with invasive growth types of colorectal cancer.
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DOI：
10.3892/or.2016.5202
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发表时间：
2016-12
期刊：
影响因子：
4.2
通讯作者：
Kijima H
中科院分区：
文献类型：
--
作者：
Takatsuna M;Morohashi S;Yoshizawa T;Hirai H;Haga T;Ota R;Saito K;Wu Y;Seino H;Aoyagi Y;Terai S;Kijima H
结直肠癌（CRC）的侵袭性生长类型和肌成纤维细胞的数量与组织病理学因素如淋巴结和肝转移以及局部复发相关。然而，很少有研究评估CRC中浸润性生长类型和肌成纤维细胞分布之间的关联。我们的目的是评估结直肠癌的临床病理因素与两种浸润性生长类型，即扩张型和浸润型之间的关系。我们将150例pT3 CRC分为扩张型和浸润型，并测量了三个组织层的肌成纤维细胞密度：粘膜下层（SM）、固有肌层（MP）和浆膜下（SS）。我们比较了这两种浸润性生长类型，并分析了临床病理因素与肌成纤维细胞密度之间的关系。浸润型肌成纤维细胞密度明显高于扩张型（P<0.05）。浸润型淋巴结转移阳性组MP中肌成纤维细胞密度明显高于淋巴结转移阴性组（P<0.001）。在浸润型中，淋巴管浸润程度高组MP内肌成纤维细胞密度明显高于淋巴管浸润程度低组（P<0.01）。这些结果表明，肌成纤维细胞参与更多的浸润型相比，扩展型的CRC。与扩张型相比，MP中存在的肌成纤维细胞似乎在浸润型的恶性潜能中发挥重要作用。
Both the invasive growth types of colorectal cancer (CRC) and the number of myofibroblasts have been associated with histopathological factors such as lymph node and liver metastasis, and local recurrence. However, there are few studies, that have assessed the association between invasive growth type and myofibroblast distribution in CRC. We aimed to evaluate the relationship between the clinicopathological factors of CRC and two invasive growth types, the expanding and infiltrating types. We categorized 150 cases of pT3 CRC into the expanding and infiltrating types and measured the myofibroblast density of three histological layers: the submucosa (SM), the muscularis propria (MP) and the subserosa (SS). We compared these two invasive growth types and analyzed the relationship between clinicopathological factors and myofibroblast density. Myofibroblast density was significantly higher in the infiltrating type than that in the expanding type (P<0.05). In the lymph node metastasis-positive group of the infiltrating type, myofibroblast density in MP was significantly higher than that in the lymph node metastasis-negative group (P<0.001). In the infiltrating type, the group with the higher level of lymphatic invasion had a significantly higher density of myofibroblasts in the MP than the group with the lower level of lymphatic invasion (P<0.01). These results suggest that myofibroblasts participate more in the infiltrating type compared with the expanding type of CRC. It would appear that myofibroblasts present in the MP play an important role in the malignant potential of the infiltrating type compared to the expanding type.
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影响因子：
3.4
作者：
Ueno, H.;Hase, K.;Mochizuki, H.
通讯作者：
Mochizuki, H.
影响因子：
3.7
作者：
Morikawa T;Kuchiba A;Qian ZR;Mino-Kenudson M;Hornick JL;Yamauchi M;Imamura Y;Liao X;Nishihara R;Meyerhardt JA;Fuchs CS;Ogino S
通讯作者：
Ogino S
DOI：
10.1158/1541-7786.mcr-12-0307
发表时间：
2012-11
期刊：
Molecular cancer research : MCR
影响因子：
--
作者：
Karagiannis GS;Poutahidis T;Erdman SE;Kirsch R;Riddell RH;Diamandis EP
通讯作者：
Diamandis EP
影响因子：
6.4
作者：
DIMANCHEBOITREL, MT;VAKAET, L;MARTIN, F
通讯作者：
MARTIN, F
影响因子：
2.4
作者：
Nakayama, H;Enzan, H;Hiroi, M
通讯作者：
Hiroi, M