Fluorescence optical diffusion tomography
Fluorescence optical diffusion tomography
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DOI：
10.1364/ao.42.003081
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发表时间：
2003-06-01
期刊：
影响因子：
1.9
通讯作者：
Millane, RP
中科院分区：
文献类型：
--
作者：
Milstein, AB;Oh, S;Millane, RP
提出了一种非线性贝叶斯优化方案，用于重建生物组织等混浊介质中的荧光产量和寿命、吸收系数和扩散系数。该方法利用激发和发射波长的测量来重建所有未知参数。通过模拟以及对含有荧光剂吲哚菁绿的组织模型的实验数据的应用，证明了重建算法的有效性。 (C) 2003 年美国光学学会。
A nonlinear, Bayesian optimization scheme is presented for reconstructing fluorescent yield and lifetime, the absorption coefficient, and the diffusion coefficient in turbid media, such as biological tissue. The method utilizes measurements at both the excitation and the emission wavelengths to reconstruct all unknown parameters. The effectiveness of the reconstruction algorithm is demonstrated by simulation and by application to experimental data from a tissue phantom containing the fluorescent agent Indocyanine Green. (C) 2003 Optical Society of America.