Prevalence of obstructive coronary artery disease in patients undergoing lung transplantation: case series and review of the literature.
Prevalence of obstructive coronary artery disease in patients undergoing lung transplantation: case series and review of the literature.
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接受肺移植的患者阻塞性冠状动脉疾病的患病率：病例系列和文献综述。
DOI：
10.1002/ccd.25261
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Keeley,EllenC
中科院分区：
文献类型：
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作者：
Jones,RobertM;Enfield,KyleB;Mehrad,Borna;Keeley,EllenC
背景：冠状动脉造影通常在肺移植前进行，但其效用尚未得到证实。方法：我们对连续接受冠状动脉造影作为肺移植术前评估一部分的患者进行了单中心回顾性分析，并回顾了先前系列的文献。结果共纳入89例患者，其中男48例，女41例。梗阻性（≥70%狭窄）冠心病9例（10%），非梗阻性（<70%狭窄）冠心病24例（27%），56例（63%）患者无血管造影证据。我们找到了13篇先前发表的文献，其中共有1998例患者在肺移植前接受了冠状动脉造影。在我们的89例患者中，11%发现阻塞性CAD。结论：考虑到肺移植患者中阻塞性CAD的患病率较低，血管造影的固有风险，以及检测阻塞性CAD的益处尚未得到证实，常规冠状动脉造影在这一人群中的应用需要在前瞻性研究中验证。©2013 Wiley期刊公司
BackgroundCoronary angiography is commonly performed prior to lung transplantation, but its utility is unproven.MethodsWe conducted a single‐center retrospective analysis of consecutive patients referred for coronary angiography as part of a pre‐operative evaluation for lung transplantation and reviewed the literature for prior series.ResultsA total of 89 patients, 48 men and 41 women were included. Obstructive (≥70% stenosis) CAD was present in 9 (10%), non‐obstructive (<70% stenosis) CAD in 24 (27%), and no angiographic evidence of CAD in 56 (63%) patients. We found 13 previously published series in the literature, in which a total of 1998 patients underwent coronary angiography pre‐lung transplant. Together with our 89 patients, obstructive CAD was found in 11%.ConclusionsIn conclusion, given the low prevalence of obstructive CAD in patients referred for lung transplantation, the inherent risk of angiography, and unproven benefit of detection of obstructive CAD, the utility of routine coronary angiography in this population requires validation in prospective studies. © 2013 Wiley Periodicals, Inc.