Trifunctional Graphene Quantum Dot@LDH Integrated Nanoprobes for Visualization Therapy of Gastric Cancer
Trifunctional Graphene Quantum Dot@LDH Integrated Nanoprobes for Visualization Therapy of Gastric Cancer
复制标题
三功能石墨烯量子点@LDH集成纳米探针用于胃癌可视化治疗
DOI：
10.1002/adhm.202100512
复制
发表时间：
2021-06-10
影响因子：
10
通讯作者：
Wang, Shilong
中科院分区：
文献类型：
--
作者：
Wu, Bin;Li, Kun;Wang, Shilong
近年来，可视化技术已成为肿瘤治疗的发展趋势。石墨烯量子点（GQDs）优越的光学特性使其成为肿瘤诊断的理想候选者，但其肿瘤靶向和载药能力仍不理想用于治疗。先前的研究制备了具有稳定荧光的硫掺杂石墨烯量子点（SGQDs）。通过层状双氢氧化物（LDHs）和依托泊苷（VP16）相结合，设计了一种可靠的策略，用于精确的可视化治疗。三功能LDH@SGQD-VP16集成纳米探针可以同时实现靶向聚集，荧光可视化和化疗。LDH@SGQD-VP16可在肿瘤微环境中积累，具有ph敏感性和体内长期的光稳定性，可为肿瘤靶向、实时成像和效果跟踪提供基础。在HGC-27细胞中，VP16的治疗作用增强，毒副作用减弱，LDH@SGQD-VP16引起的细胞凋亡比单独使用VP16的细胞凋亡高约2.7倍。本研究为LDH@SGQD-VP16作为一种潜在的多功能胃癌可视化治疗药物提供了理论和实验基础。
Visualization technology has become a trend in tumor therapy in recent years. The superior optical properties of graphene quantum dots (GQDs) make them suitable candidates for tumor diagnosis, but their tumor targeting and drug-carrying capacities are still not ideal for treatment. Sulfur-doped graphene quantum dots (SGQDs) with stable fluorescence are prepared in a previous study. A reliable strategy by associating layered double hydroxides (LDHs) and etoposide (VP16) is designed for precise visualization therapy. Trifunctional LDH@SGQD-VP16 integrated nanoprobes can simultaneously achieve targeted aggregation, fluorescence visualization, and chemotherapy. LDH@SGQD-VP16 can accumulate in the tumor microenvironment, owing to pH-sensitive properties and long-term photostability in vivo, which can provide a basis for cancer targeting, real-time imaging, and effect tracking. The enhanced therapeutic and attenuated side effects of VP16 are demonstrated, and the apoptosis caused by LDH@SGQD-VP16 is approximate to 2.7 times higher than that of VP16 alone, in HGC-27 cells. This work provides a theoretical and experimental basis for LDH@SGQD-VP16 as a potential multifunctional agent for visualization therapy of gastric cancer.