Splitting of the Extraocular Horizontal Rectus Muscle in Congenital Cranial Dysinnervation Disorders
Splitting of the Extraocular Horizontal Rectus Muscle in Congenital Cranial Dysinnervation Disorders
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DOI：
10.1016/j.ajo.2008.09.015
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发表时间：
2009-03-01
影响因子：
4.2
通讯作者：
Ohtsuki, Hiroshi
中科院分区：
文献类型：
--
作者：
Okanobu, Hirotaka;Kono, Reika;Ohtsuki, Hiroshi
目的：通过眼眶磁共振成像（MRI）分析由颅神经核或其轴突连接发育异常引起的先天性颅神经支配障碍患者的水平直肌眼外肌（EOMs）。设计：病例系列，回顾性分析。方法：分析4例先天性动眼肌麻痹患者、26例先天性上斜肌麻痹患者和5例Duane综合征患者的眼眶MRI水平直肌EOMs形态。行1.5特斯拉(T)和3T MRI成像，获得垂直于眶长轴和平行于眶长轴的准冠状面和矢状面，切片厚度分别为3和2 mm。结果：35例患者中有4例（11%）出现水平直面EOMs分裂。5例Duane综合征患者中2例（40%）、26例先天性上斜肌麻痹患者中1例（4%）、4例动眼肌麻痹患者中1例（25%）出现劈裂，6例正常人和12例获得性脑神经麻痹患者均未出现劈裂。结论：由于包括Duane综合征在内的先天性神经支配障碍患者中存在水平直肌EOMs的分裂，因此Sevel认为水平直肌EOMs起源于上、下中胚层复合物的理论是合理的。[J]中华眼科杂志，2009;47(2):555 -556。(C) 2009年Elsevier Inc.版权所有。)
PURPOSE: To analyze the horizontal rectus extraocular muscles (EOMs) by orbital magnetic resonance imaging (MRI) in patients with congenital cranial dysinnervation disorders that arises from abnormal development of cranial nerve nuclei or their axonal connections.DESIGN: Case series, retrospective analysis.METHODS: The morphology of the horizontal rectus EOMs was analyzed in orbital MRI on 4 patients with congenital oculomotor palsy, 26 with congenital superior oblique palsy, and five with Duane syndrome. Orbital imaging was performed by 1.5 tesla (T) and 3T MRI, and quasi coronal and sagittal images perpendicular and par, allel to the long axis of the orbit were obtained at slice thicknesses of 3 and 2 mm.RESULTS: The horizontal rectus EOMs were split in 4 of the 35 patients (11%). Splitting was observed in 2 of the five patients (40%) with Duane syndrome, one of the 26 patients (4%) with congenital superior oblique palsy, and I of the 4 patients (25%) with oculomotor palsy, but in none of the 6 normal subjects and 12 patients with acquired cranial nerve palsy.CONCLUSION: Since splitting of the horizontal rectus EOMs was noted in patients with congenital dysinnervation disorders, including Duane syndrome, Sevel's theory that the horizontal rectus EOMs develop from the superior and inferior mesodermal complexes is considered to be reasonable. (Am J Ophthalmol 2009;147:550-556. (C) 2009 by Elsevier Inc. All rights reserved.)