Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: A five-year prospective study
Attenuated IGF-1 predicts all-cause and cardiovascular mortality in a Black population: A five-year prospective study
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DOI：
10.1177/2047487316661436
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发表时间：
2016-11-01
影响因子：
8.3
通讯作者：
Huisman, Hugo W.
中科院分区：
文献类型：
--
作者：
Schutte, Aletta E.;Conti, Elena;Huisman, Hugo W.
Background Inconsistent findings are reported on whether insulin-like growth factor-1 (IGF-1) is protective or harmful in predicting hypertension, carotid wall thickness and mortality. We determined the five-year prognostic value of IGF-1 for these outcomes in a large Black population prone to hypertension and cardiovascular disease.Design A longitudinal study as part of the PURE (Prospective Urban and Rural Epidemiology) study, North West Province, South Africa.Methods We measured IGF-1 and IGF binding protein-3 (IGFBP-3) in 1038 HIV-uninfected participants (age range 32-94 years) and assessed blood pressure, carotid intima-media thickness and mortality.Results Over five years 116 deaths occurred. Baseline IGF-1 was similar in survivors and non-survivors (p=0.50), but tended to be higher in survivors upon adjustment for IGFBP-3 and covariates (p=0.061). Normotensives and hypertensives (p=0.072), and those with carotid intima-media thickness
