Effects of compositions of dimethyl-beta-cyclodextrins on enantiomer separations by cyclodextrin modified capillary zone electrophoresis.
Effects of compositions of dimethyl-beta-cyclodextrins on enantiomer separations by cyclodextrin modified capillary zone electrophoresis.
复制标题
二甲基-β-环糊精组合物对环糊精修饰毛细管区带电泳对映异构体分离的影响。
DOI：
10.1016/s0731-7085(98)00091-0
复制
发表时间：
1998
影响因子：
3.4
通讯作者：
N. Tanaka
中科院分区：
文献类型：
--
作者：
K. Otsuka;S. Honda;Jun Kato;S. Terabe;K. Kimata;N. Tanaka
在以二甲基-β-环糊精（DM-β-CD）为手性选择剂的毛细管区带电泳对映体分离中，不同厂家的DM-β-CD对映体的选择性有时存在显著差异。其原因是由于这些商业产品之间的组成差异，这是由液相色谱（LC）分析所示。对于来自一个供应商的商业DM-β-CD，通过制备型LC获得两种主要组分。对这两种组分进行NMR光谱和质谱分析，以估计每种组分的结构。结果表明，商品化产物由七（2，6-二-O-二甲基）-β-CD和六（2，6-二-O-甲基）-单（2，3，6-三-O-甲基）-β-CD组成。有时在这两种组分（包括原始DM-β-CD）之间观察到不同的对映选择性。
In enantiomeric separation by capillary zone electrophoresis using dimethyl-β-cyclodextrin (DM-β-CD) as a chiral selector, enantioselectivities were sometimes significantly different among DM-β-CDs from five different suppliers. The reason was due to the difference in the compositions among these commercial products, which was shown by the liquid chromatographic (LC) analysis. As for commercial DM-β-CD from one supplier, two major components were obtained by preparative LC. NMR spectroscopic and mass spectrometric analyses of these two components were performed to estimate the structure of each component. The results implied that the commercial products consist of heptakis(2,6-di-O-dimethyl)-β-CD and hexakis(2,6-di-O-methyl)-mono(2,3,6-tri-O-methyl)-β-CD. Sometimes different enantioselectivities were observed between these two components including the original DM-β-CD.