The integrative role of the M1 in motor sequence learning
The integrative role of the M1 in motor sequence learning
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DOI：
10.1016/j.neulet.2021.136081
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发表时间：
2021-07-02
影响因子：
2.5
通讯作者：
Sadato, Norihiro
中科院分区：
文献类型：
--
作者：
Hamano, Yuki H.;Sugawara, Sho K.;Sadato, Norihiro
初级运动皮层（M1）在运动学习中至关重要。M1是否对强调速度而形成的连续手指敲击的运动痕迹进行编码仍然没有定论。记忆痕迹的活动状态很难与运动执行本身区分开来。由于准备活动反映了即将到来的运动参数，我们假设，由不同的学习模式产生的运动记忆痕迹的检索反映为M1的准备活动的学习相关的增加。为了验证这一假设，我们评估了准备活动的学习过程中的顺序手指轻敲与非优势左手使用7 T功能磁共振成像。参与者在尽可能快地执行敲击序列（最大模式）或通过序列指定视觉提示以2 Hz的恒定速度起搏（恒定模式）之间交替。我们发现，在最大模式和恒定模式下，覆盖双侧前顶内沟和顶下小叶延伸到右侧M1的网络中的准备活动与训练相关增加。这些发现表明，尽管训练模式不同，但M1作为运动输出的最后效应器，整合了通过网络分布的运动记忆痕迹。
The primary motor cortex (M1) is crucial in motor learning. Whether the M1 encodes the motor engram for sequential finger tapping formed by an emphasis on speed is still inconclusive. The active states of engrams are hard to discriminate from the motor execution per se. As preparatory activity reflects the upcoming movement parameters, we hypothesized that the retrieval of motor engrams generated by different learning modes is reflected as a learning-related increase in the preparatory activity of the M1. To test this hypothesis, we evaluated the preparatory activity during the learning of sequential finger-tapping with the non-dominant left hand using a 7T functional MRI. Participants alternated between performing a tapping sequence as quickly as possible (maximum mode) or at a constant speed of 2 Hz paced by a sequence-specifying visual cue (constant mode). We found a training-related increase in preparatory activity in the network covering the bilateral anterior intraparietal sulcus and inferior parietal lobule extending to the right M1 during the maximum mode and the right M1 during the constant mode. These findings indicate that the M1, as the last effector of the motor output, integrates the motor engram distributed through the networks despite training mode differences.