Morphology of the insula in relation to hearing status and sign language experience.
Morphology of the insula in relation to hearing status and sign language experience.
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DOI：
10.1523/jneurosci.3141-08.2008
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发表时间：
2008-11-12
影响因子：
5.3
通讯作者：
Damasio, Hanna
中科院分区：
文献类型：
--
作者：
Allen, John S.;Emmorey, Karen;Bruss, Joel;Damasio, Hanna
我们调查了听觉剥夺和/或手语暴露在发展过程中是否改变了人类大脑的宏观神经解剖学。体积分析的基础上，从25个先天性耳聋的主题谁是美国手语（ASL）的本地用户，25个听力主题没有知识的ASL，和16个听力主题谁在聋人家庭长大，是本地ASL签名的MRI数据。听力状态和手语经验都与音量的显著变化有关。与两个听力组相比，聋人受试者表现出显着增加，在左后岛叶，我们假设这可能是与依赖唇读和发音为基础的（而不是发音为基础的）代表性的讲话聋人的灰质的量。与听力正常者相比，听力正常者和听力正常者的右颞叶白色物质的体积都有所增加。我们假设，不同的形态学的右颞叶手语签名可能会产生增强连接性，从而增加依赖于跨模态的感觉整合手语相比，口语。
We investigated whether auditory deprivation and/or sign language exposure during development alters the macroscopic neuroanatomy of the human insula. Volumetric analyses were based on MRI data from 25 congenitally deaf subjects who were native users of American Sign Language (ASL), 25 hearing subjects with no knowledge of ASL, and 16 hearing subjects who grew up in deaf families and were native ASL signers. Significant variation in insula volume was associated with both hearing status and sign language experience. Compared with both hearing groups, deaf subjects exhibited a significant increase in the amount of gray matter in the left posterior insular lobule, which we hypothesize may be related to the dependence on lip-reading and articulatory-based (rather than auditory-based) representations of speech for deaf individuals. Both deaf and hearing signers exhibited an increased volume of white matter in the right insula compared with hearing nonsigners. We hypothesize that the distinct morphology of the right insula for ASL signers may arise from enhanced connectivity resulting from an increased reliance on cross-modal sensory integration in sign language compared with spoken language.