Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea
Total Cholesterol and Cancer Risk in a Large Prospective Study in Korea
复制标题
DOI：
10.1200/jco.2010.31.5200
复制
发表时间：
2011-04-20
影响因子：
45.3
通讯作者：
Samet, Jonathan M.
中科院分区：
文献类型：
--
作者：
Kitahara, Cari M.;de Gonzalez, Amy Berrington;Samet, Jonathan M.
为了进一步阐明总胆固醇和癌症之间的关系，这仍然不清楚。方法我们前瞻性地研究了总胆固醇和特定部位和所有癌症发病率之间的关系，719名韩国成年人参加了国家健康保险公司，他们在1992年至1995年接受了标准化的两年一次的体检，并观察了14年，直到癌症诊断或结果随访期间，53，944名男性和24，475名女性被诊断为原发性癌症。与低于160 mg/dL的水平相比，高总胆固醇（>= 240 mg/dL）与前列腺癌呈正相关（风险比[HR]，1.24; 95% CI，1.07 - 1.44; P趋势= .001）和结肠癌（HR，1.12; 95% CI，1.00至1.25; P趋势= 0.05），女性乳腺癌（HR，1.17; 95% CI，1.03至1.33; P趋势= 0.03）。总胆固醇较高与肝癌发病率较低相关（男性：HR，0.42; 95%CI，0.38至0.45; P趋势< .001;女性：HR，0.32; 95%CI，0.27至0.39; P趋势< .001），胃癌（男性：HR，0.87; 95%CI，0.82至0.93; P趋势<.001），
PurposeTo further clarify the relationship between total cholesterol and cancer, which remains unclear.MethodsWe prospectively examined the association between total cholesterol and site-specific and all-cancer incidence among 1,189,719 Korean adults enrolled in the National Health Insurance Corporation who underwent a standardized biennial medical examination in 1992 to 1995 and were observed for 14 years until cancer diagnosis or death.ResultsOver follow-up, 53,944 men and 24,475 women were diagnosed with a primary cancer. Compared with levels less than 160 mg/dL, high total cholesterol (>= 240 mg/dL) was positively associated with prostate cancer (hazard ratio [HR], 1.24; 95% CI, 1.07 to 1.44; P trend = .001) and colon cancer (HR, 1.12; 95% CI, 1.00 to 1.25; P trend = .05) in men and breast cancer in women (HR, 1.17; 95% CI, 1.03 to 1.33; P trend = .03). Higher total cholesterol was associated with a lower incidence of liver cancer (men: HR, 0.42; 95% CI, 0.38 to 0.45; P trend < .001; women: HR, 0.32; 95% CI, 0.27 to 0.39; P trend < .001), stomach cancer (men: HR, 0.87; 95% CI, 0.82 to 0.93; P trend