Investigating the transcriptional control of cardiovascular development.
Investigating the transcriptional control of cardiovascular development.
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DOI：
10.1161/circresaha.116.302832
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发表时间：
2015-02-13
影响因子：
20.1
通讯作者：
Bruneau BG
中科院分区：
文献类型：
--
作者：
Kathiriya IS;Nora EP;Bruneau BG
数千个基因的转录调控指导心脏发育的复杂形态发生和分子事件。心脏转录因子（TF）通过与辅因子（包括染色质修饰酶）相互作用以及与一系列调控DNA元件结合，在分化的每个阶段编排基因表达。在这里，我们提出了显着的例子相关的心血管发展和心脏病和审查技术，可以提高我们的心血管生物学的理解。我们讨论了心脏转录因子，顺式调控元件和染色质之间的相互作用，作为动态调控网络，协调心脏基因表达程序的顺序部署。
Transcriptional regulation of thousands of genes instructs complex morphogenetic and molecular events for heart development. Cardiac transcription factors (TFs) choreograph gene expression at each stage of differentiation by interacting with co-factors, including chromatin-modifying enzymes, and by binding to a constellation of regulatory DNA elements. Here, we present salient examples relevant to cardiovascular development and heart disease and review techniques that can sharpen our understanding of cardiovascular biology. We discuss the interplay between cardiac TFs, cis-regulatory elements and chromatin as dynamic regulatory networks, to orchestrate sequential deployment of the cardiac gene expression program.