Effect of Plasma on Structure and Permeability of Epidermal Layer of Pig Skin
Effect of Plasma on Structure and Permeability of Epidermal Layer of Pig Skin
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通讯作者：
J. Krištof;Hideto Miyamoto;Marrius Blajan;Kazuo Shimizu
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作者：
J. Krištof;Hideto Miyamoto;Marrius Blajan;Kazuo Shimizu
- 经皮给药需要改变皮肤的性质以增加其渗透性。研究了等离子体射流治疗角质层的效果。对皮肤横截面进行组织学观察，其特征在于等离子体的蚀刻效果取决于处理时间。用ATR-FTIR光谱观察了蛋白质和脂质构象的变化。等离子体射流引起的结构变化观察到的带宽增加和减少的吸收的脂质振动带。这些变化可以增加脂质结构的灵活性和皮肤的渗透性。
— Transdermal drug delivery requires changes of properties of the skin to increase its permeability. Effect of plasma jet treatment of Stratum corneum was investigated. Histological observation of the cross section of the skin characterized etching effect of plasma depending on the treatment time. Changes of protein and lipid conformations were observed by ATR-FTIR spectroscopy. Plasma jet caused structural changes observed by increase of bandwidth and decrease of absorbance of the lipid vibrational bands. These changes can increase flexibility of lipid structures and permeability of the skin.