Association of sirtuins (SIRT1-7) with lung and intestinal diseases
Association of sirtuins (SIRT1-7) with lung and intestinal diseases
复制标题
Sirtuins (SIRT1-7) 与肺和肠道疾病的关联
DOI：
10.1007/s11010-022-04462-9
复制
发表时间：
2022-05-20
影响因子：
4.3
通讯作者：
Li, Ning
中科院分区：
文献类型：
--
作者：
Chen, Yuhan;Zhou, Di;Li, Ning
“肺与大肠表里相通”是中医的重要内容之一。该理论描述了肺和肠在疾病治疗中的作用。 “肺肠轴”是中医“肺大肠表里相通”理论的现代延伸。 Sirtuin (SIRT) 是一种烟酰胺腺嘌呤二核苷酸 (NAD(+)) 依赖性酶家族，具有脱乙酰酶特性，从细菌到人类都高度保守。 Sirtuin 定义了人类细胞中的七种沉默调节蛋白 (SIRT1-7)。它可以调节衰老、新陈代谢和某些疾病。目前的研究表明sirtuins具有双重特性，在癌症中既充当肿瘤促进剂又充当肿瘤抑制剂。本文比较总结了 SIRT1-7 在肠和肺（炎症性疾病和肿瘤）中的作用，以及靶向 SIRT 家族 microRNA 和炎症或肿瘤调节剂的启动子/抑制子作用。 Sirtuins作为治疗肠道和呼吸道疾病的药物靶点具有巨大的潜力。同时，也可能为未来药物靶点研究提供新思路。
"Exterior-interior correlation between the lung and large intestine" is one of the important contents of traditional Chinese medicine. This theory describes the role of the lung and the intestine in association with disease treatment. The "lung-gut" axis is a modern extension of the "exterior-interior correlation between lung and large intestine" theory in TCM. Sirtuin (SIRT) is a nicotinamide adenine dinucleotide (NAD(+))-dependent enzyme family with deacetylase properties, which is highly conserved from bacteria to humans. The sirtuin defines seven silencing regulatory proteins (SIRT1-7) in human cells. It can regulate aging, metabolism, and certain diseases. Current studies have shown that sirtuins have dual characteristics, acting as both tumor promoters and tumor inhibitors in cancers. This paper provides a comparative summary of the roles of SIRT1-7 in the intestine and lung (both inflammatory diseases and tumors), and the promoter/suppressor effects of targeting SIRT family microRNAs and modulators of inflammation or tumors. Sirtuins have great potential as drug targets for the treatment of intestinal and respiratory diseases. Meanwhile, it may provide new ideas of future drug target research.