A higher dose of vitamin d reduces the risk of falls in nursing home residents: A randomized, multiple-dose study
A higher dose of vitamin d reduces the risk of falls in nursing home residents: A randomized, multiple-dose study
复制标题
DOI：
10.1111/j.1532-5415.2007.01048.x
复制
发表时间：
2007-02-01
影响因子：
6.3
通讯作者：
Kiel, Douglas P.
中科院分区：
文献类型：
--
作者：
Broe, Kerry E.;Chen, Tai C.;Kiel, Douglas P.
目的：确定四种维生素D补充剂对老年养老院居民跌倒风险的影响。设计：对先前进行的随机临床试验进行二次数据分析。设置：725个床位的长期护理机构。对象：124名养老院居民(平均年龄)。干预：参与者被随机分配到四种维生素D补充剂(200IU、400IU、600IU或800IU)或安慰剂中的一种，每天接受一种维生素D补充剂(200IU、400IU、600IU或800IU)或安慰剂，为期5个月。测量：使用设施事件跟踪数据库评估跌倒人数和跌倒次数。结果：在5个月的研究期间，安慰剂组跌倒的比例为44%(11/25)，200IU组为58%(15/26)，400IU组为60%(15/25)，600IU组为60%(15/25)，800IU组为20%(5/23)。800IU组的参与者在5个月内的调整后跌倒发生率比服用安慰剂的参与者低72%(比率比=0.28；95%可信区间=0.11-0.75)。在任何其他补充组中，调整后的跌倒发生率与安慰剂相比没有显著差异。结论：与服用低剂量维生素D的疗养院居民相比，最高维生素D组(800IU)的疗养院居民摔倒的次数和5个月内跌倒的发生率都较低。在老年疗养院居民中补充足够的维生素D可以减少这一高跌倒风险群体经历的跌倒次数。
OBJECTIVES: To determine the effect of four vitamin D supplement doses on falls risk in elderly nursing home residents.DESIGN: Secondary data analysis of a previously conducted randomized clinical trial.SETTING: Seven hundred twenty-five-bed long-term care facility.PARTICIPANTS: One hundred twenty-four nursing home residents (average age 89).INTERVENTION: Participants were randomly assigned to receive one of four vitamin D supplement doses (200 IU, 400 IU, 600 IU, or 800 IU) or placebo daily for 5 months.MEASUREMENTS: Number of fallers and number of falls assessed using facility incident tracking database.RESULTS: Over the 5-month study period, the proportion of participants with falls was 44% in the placebo group (11/25), 58% (15/26) in the 200 IU group, 60% (15/25) in the 400 IU group, 60% (15/25) in the 600 IU group, and 20% (5/23) in the 800 IU group. Participants in the 800 IU group had a 72% lower adjusted-incidence rate ratio of falls than those taking placebo over the 5 months (rate ratio=0.28; 95% confidence interval=0.11-0.75). No significant differences were observed for the adjusted fall rates compared to placebo in any of the other supplement groups.CONCLUSION: Nursing home residents in the highest vitamin D group (800 IU) had a lower number of fallers and a lower incidence rate of falls over 5 months than those taking lower doses. Adequate vitamin D supplementation in elderly nursing home residents could reduce the number of falls experienced by this high falls risk group.