Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK
Common variation at the adiponectin locus is not associated with colorectal cancer risk in the UK
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DOI：
10.1093/hmg/ddp109
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发表时间：
2009-05-15
影响因子：
3.5
通讯作者：
Tomlinson, Ian
中科院分区：
文献类型：
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作者：
Carvajal-Carmona, Luis G.;Spain, Sarah;Tomlinson, Ian
最近的一项研究检查了美国两个病例对照结直肠癌（CRC）系列中脂联素位点（ADIPOQ）的常见遗传变异，并报道了该基因（rs266729） 5'区域的单核苷酸多态性（SNP）与疾病风险降低之间的正相关。为了尝试重复先前报道的关联，我们检查了基于英国人群的两个CRC全基因组关联研究的数据。第一组包括931例家族性结直肠癌病例和929例无癌对照。第二组包括来自两项临床试验的1216名Dukes B期或C期crc患者和来自1958年出生队列的1436名对照。我们测试了结直肠癌风险与ADIPOQ基因周围250kb区域的82个snp之间的关系；其中9个snp位于编码区和启动子区。在两个队列中任何一种模型下进行多次检测校正后，检测的标记物均未与结直肠癌风险显著相关。数据的荟萃分析也没有发现任何关联。因此，我们未能在英国复制ADIPOQ常见变异与CRC风险之间的关联，并提示先前的报告要么是人群特异性的，要么是假阳性的结果。
A recent study examined common genetic variants at the adiponectin locus (ADIPOQ) in two case-control colorectal cancer (CRC) series from the USA and reported a positive association between a single nucleotide polymorphism (SNP) in the 5' region of the gene (rs266729) and decreased disease risk. In an attempt to replicate the previously reported association, we examined data from two CRC genome-wide association studies based on the UK population. The first cohort comprised 931 familial colorectal tumour cases and 929 cancer-free controls. The second included 1216 individuals with Dukes stage B or C CRCs from two clinical trials and 1436 controls from the 1958 Birth Cohort. We tested associations between CRC risk and 82 SNPs in a region of 250 kb around the ADIPOQ gene; nine of these SNPs were located in the coding and promoter regions. None of the markers tested was significantly associated with CRC risk after correction for multiple testing under any of the models in any of the two cohorts. A meta-analysis of the data also failed to detect any association. We, therefore, failed to replicate an association between common variants at ADIPOQ and CRC risk in the UK, and suggest that the previous report is either population-specific or a false-positive result.