Relative adrenal insufficiency in the preterm and term infant
Relative adrenal insufficiency in the preterm and term infant
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DOI：
10.1038/jp.2009.24
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发表时间：
2009-05-01
影响因子：
2.9
通讯作者：
Watterberg, K. L.
中科院分区：
文献类型：
--
作者：
Fernandez, E. F.;Watterberg, K. L.
面对疾病或压力时皮质醇的释放对生存至关重要。当患者的皮质醇反应不足以应对疾病或压力的程度时，就会发生相对肾上腺功能不全。许多研究已经证明了重症成人中存在相对肾上腺功能不全，以及其与发病率和死亡率增加的相关性。越来越多的证据表明，相对肾上腺功能不全可能是危重新生儿血流动力学不稳定和低血压的病因，但与成人人群相比，这一人群的数据仍然很少。需要随机对照试验来评估糖皮质激素治疗早产儿和足月新生儿因相对肾上腺皮质功能不全引起的心血管功能不全的疗效和安全性。围产期杂志（2009）29，S44-S49; doi：10.1038/jp.2009.24
Cortisol release in the face of illness or stress is vital for survival. Relative adrenal insufficiency occurs when a patient's cortisol response is inadequate for the degree of illness or stress. Numerous studies have documented the existence of relative adrenal insufficiency in critically ill adults, and its association with increased morbidity and mortality. There is increasing evidence that relative adrenal insufficiency may be an etiology for hemodynamic instability and hypotension in the critically ill newborn, but compared with the adult population, there is still a paucity of data in this population. Randomized controlled trials are needed to evaluate the efficacy and safety of glucocorticoids for the treatment of cardiovascular insufficiency due to relative adrenal insufficiency in ill preterm and term newborn infants. Journal of Perinatology (2009) 29, S44-S49; doi:10.1038/jp.2009.24