STUDIES ON COPPER METABOLISM .9. THE TRANSPORTATION OF COPPER IN BLOOD
STUDIES ON COPPER METABOLISM .9. THE TRANSPORTATION OF COPPER IN BLOOD
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DOI：
10.1172/jci102752
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发表时间：
1953-01-01
影响因子：
15.9
通讯作者：
WINTROBE, MM
中科院分区：
文献类型：
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作者：
GUBLER, CJ;LAHEY, ME;WINTROBE, MM
有证据表明，铜在人、大鼠、犬和猪血浆中至少以2种形式存在。仅在通过用HCl处理从蛋白质中除去后才与二乙基二硫代氨基甲酸钠反应的级分对应于由Holmberg和Laurell分离的Cu α-球蛋白（血浆铜蓝蛋白）。这一部分构成了大约。人、大鼠、犬和猪血浆中正常存在的Cu分别为96%、99%、88%和58%。血浆中其余的Cu以直接与氨基甲酸酯试剂反应的形式存在，但与间接反应部分一样，在生理pH范围内也不可透析。妊娠期高铜血症和人类受试者感染中的高铜血症以及与动物实验诱导感染相关的高铜血症是由于间接反应分数增加所致。口服或静脉注射后出现高铜血症。admn.的Cu是由于直接反应分数的增加。
Evidence is presented that Cu is present in human, rat, dog and pig plasma in at least 2 forms. The fraction which reacts with Na diethyldithiocarbamate only after removal from the protein by treatment with HC1 corresponds to the Cu alpha-globulin (ceruloplasmin) isolated by Holmberg and Laurell. This fraction constitutes approx. 96, 99, 88 and 58% of the Cu normally present in human, rat, dog and pig plasma, respectively. The remainder of the Cu in plasma is in a form which reacts directly with the carbamate reagent but, like the indirect-reacting fraction, is also nondialyzable within the physiologic pH range. The hypercupremia of pregnancy and that in infections in human subjects and in association with experimentally induced infections in animals is due to an increase in the indirect-reacting fraction. The hypercupremia which follows the oral or intraven. admn. of Cu is due to an increase in the direct-reacting fraction.