Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury
Distinct pattern of neuronal degeneration in the fetal rat brain induced by consecutive transplacental administration of methylmercury
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DOI：
10.1016/s0006-8993(00)01964-8
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发表时间：
2000-03-24
期刊：
影响因子：
2.9
通讯作者：
Takahashi, H
中科院分区：
文献类型：
--
作者：
Kakita, A;Wakabayashi, K;Takahashi, H
研究了甲基汞(MeHg)对胎鼠脑的经胎盘神经毒性。成年雌性大鼠分别给予1、2、3 mg/kg/d的氯化甲基汞(MMC)灌胃5天或12天后交配。随后，他们以相同的方式服用MMC，直到妊娠结束。在胚胎第22天，对部分胎儿脑组织进行组织学检查。在脑干、扣带回、丘脑和包括下丘脑在内的大脑基底区均可见不同程度的神经元变性。神经细胞损伤的分布模式与甲基汞染毒大鼠在出生后和成年期的分布不同。这一发现表明，甲基汞中毒的病理机制在胎儿大脑中起着明显的作用。母鼠经1 mg/kg/d的MMC处理后，孕前5天和整个妊娠期间的子代存活下来，并伴有固有的脑损伤。该实验模型可作为研究甲基汞对人胎脑神经毒性的有用工具。(C)2000 Elsevier Science B.V.保留所有权利。
The transplacental neurotoxicity of methylmercury (MeHg) on the fetal rat brain was studied. Adult female rats were administered 1, 2 or 3 mg/kg/day methylmercury chloride (MMC) orally for either 5 or 12 days, and were then mated. They were subsequently administered MMC in the same manner until the end of gestation. On embryonic day 22, a proportion of the fetal brains were histologically examined. Neuronal degeneration of varying degree was detected consistently in the brain stem, cingulate cortex, thalamus and cerebral basal area, including the hypothalamus. The distribution pattern of neuronal damage was different from those in rats treated with MeHg in the postnatal or adult stages. This finding suggests that pathomechanisms in MeHg intoxication operate distinctively in the fetal brain. The offspring derived from dams treated with 1 mg/kg/day MMC for 5 pregestational days and throughout pregnancy survived with inherent brain lesions. This experimental model could be a useful tool for research on the neurotoxicity of MeHg in the human fetal brain. (C) 2000 Elsevier Science B.V. All rights reserved.