Preparation of Uniform Microspheres Using a Simple Fluidic Device and Their Crystallization into Close-Packed Lattices
Preparation of Uniform Microspheres Using a Simple Fluidic Device and Their Crystallization into Close-Packed Lattices
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DOI：
10.1002/smll.200801498
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发表时间：
2009-02-20
期刊：
影响因子：
13.3
通讯作者：
Xia, Younan
中科院分区：
文献类型：
--
作者：
Choi, Sung-Wook;Cheong, In Woo;Xia, Younan
利用简单的射流装置制备了均匀的树莓状微球，并对其结晶成密排晶格进行了研究。通过稳定的水包油（O/W）或油包水（W/O）乳液制备球体，并对紧密堆积的晶格进行扫描电子显微镜（SEM）。已经开发了各种类型的微流体装置以产生具有不同形态的微粒，例如球体、杆、盘和椭圆体。该装置提供了对乳液液滴形成的精确控制，从而产生尺寸在30至250 μm范围内的均匀微球。该技术提供了一个强大的战略，可扩展和连续生产的微球从有机和无机材料积极寻求封装的药物，染料和组织工程。
The preparation of uniform raspberry-like microspheres using a simple fluidics device and their crystallization into close-packed lattices was investigated. The spheres was developed by stable Oil-in-Water (O/W) or Water-in-Oil (W/O) emulsions and scanning Electron Microscopy (SEM) of close packed lattices was done. Various types of microfluidic devices have been developed to generate microparticles with diverse morphologies such as spheres, rods, disks and ellipsoids. The device provided precise control over the formation of emulsion droplets, leading to the production of uniform microspheres in size ranging from 30 to 250 μm. The technique provided a powerful strategy for the scalable and continuous production of microspheres from both organic and inorganic materials actively sought for encapsulation of drugs, dyes, and tissue engineering.