The mechanism of Drosophila leg development along the proximodistal axis
The mechanism of Drosophila leg development along the proximodistal axis
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DOI：
10.1111/j.1440-169x.2004.00735.x
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发表时间：
2004-04
期刊：
影响因子：
4.6
通讯作者：
T. Kojima
中科院分区：
文献类型：
--
作者：
T. Kojima
在高等生物的发育过程中，大多数模式化事件发生在生长中的组织中。因此，阐明生长组织如何形成最终形态的机制一直是发育生物学的重要课题。长期以来，脊椎动物和无脊椎动物的肢体或附件发育引起了许多研究人员的极大关注，因为它们涉及组织图案化所需的几乎所有发育过程，例如形态发生素产生位置信息，根据位置信息将组织细分为不同部分，局部细胞生长和增殖，以及粘附性的控制，细胞的运动和形状变化。果蝇腿的发育是一个很好的模型系统，在此基础上已经积累了大量的知识。本文综述了果蝇足发育机制的研究进展。
During development of higher organisms, most patterning events occur in growing tissues. Thus, unraveling the mechanism of how growing tissues are patterned into final morphologies has been an essential subject of developmental biology. Limb or appendage development in both vertebrates and invertebrates has attracted great attention from many researchers for a long time, because they involve almost all developmental processes required for tissue patterning, such as generation of the positional information by morphogen, subdivision of the tissue into distinct parts according to the positional information, localized cell growth and proliferation, and control of adhesivity, movement and shape changes of cells. The Drosophila leg development is a good model system, upon which a substantial amount of knowledge has been accumulated. In this review, the current understanding of the mechanism of Drosophila leg development is described.