Sodium MRI of a Human Transplanted Kidney
Sodium MRI of a Human Transplanted Kidney
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DOI：
10.1016/j.acra.2009.01.010
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发表时间：
2009-07-01
影响因子：
4.8
通讯作者：
Lenkinski, Robert E.
中科院分区：
文献类型：
--
作者：
Rosen, Yael;Lenkinski, Robert E.
理由和目标。肾脏的钠磁共振成像（MRI）已被用于在空间上标记钠聚集活动区域，并量化各种生理和病理生理条件下的皮质髓质钠梯度。在这个案例研究中，钠MRI的临床功能良好的移植肾wits进行，以确定其钠梯度是否可以检测和定量使用这种方法。在3 T扫描仪上进行钠MRI，将商用矩形钠表面线圈放置在下腹部可触及的移植肾上方。采用改良的三维梯度回波序列进行Na-23成像。检测到髓质内的五个主要肾锥体，并且通过基于感兴趣区域和逐像素分析来量化每个肾锥体中的皮质髓质钠梯度，导致平均髓质/皮质信噪比为1.8 +/- 0.1（n = 5），平均线性增加斜率为1.1 +/- 0.1相对任意单位/mm（n结论。本研究证实了Na-23磁共振成像在人移植肾中的可行性和可用性。需要进一步的研究来确定这项技术在肾移植患者随访中的临床意义。
Rationale and Objectives. Sodium magnetic resonance imaging (MRI) of the kidneys has been used to spatially mar) areas of sodium-concentrating activity and to quantify the corticomedullary sodium gradient in various physiologic and pathophysiologic conditions. In this case study, sodium MRI of a clinically well-functioning transplanted kidney wits performed to determine whether its sodium gradient could be detected and quantified using this method.Materials and Methods. Sodium MRI was performed on a 3T scanner with a commercial rectangular sodium surface coil placed on the lower abdomen over the palpable transplanted kidney. A three-dimensional gradient echo sequence, modified for multinuclear imaging, was applied to acquire Na-23 images.Results. Five main renal pyramids within the medulla were detected, and the corticomedullary sodium gradient wits quantified in each renal pyramid by both region of interest-based and pixel-by-pixel analyses, resulting in a mean medulla/cortex signal-to-noise ratio of 1.8 +/- 0.1 (n = 5) and a mean linear increase slope of 1.1 +/- 0.1 relative arbitrary units per mm (nConclusions. The feasibility and usability of Na-23 MRI of a human renal allograft was demonstrated. Further studies are required to determine the clinical significance of this technique in the follow-up of patients after renal transplantation.