Comparative study of the diastereoselective addition of allenyl zinc reagents to alpha-alkoxy (or silyloxy) aldehydes and imines. A straightforward synthesis of amino alcohols from imines
Comparative study of the diastereoselective addition of allenyl zinc reagents to alpha-alkoxy (or silyloxy) aldehydes and imines. A straightforward synthesis of amino alcohols from imines
复制标题
丙二烯基锌试剂与α-烷氧基（或甲硅烷氧基）醛和亚胺的非对映选择性加成的比较研究。
作者：
Poisson;Normant
烯基溴化锌与α-手性亚胺的加成反应具有很高的非对映选择性。这一结果与相应的醛的加成相反，导致了较差的非对映选择性。用Felkin-Ahn和Gaudemar-Yamamoto过渡态模型解释了反/反加合物。
The addition of allenylzinc bromides to alpha-chiral imines proceeds with very high diastereoselectivity. This result is in contrast with the addition to the corresponding aldehydes, leading to poor diastereoselectivity. The anti/anti adducts are explained by Felkin-Ahn and Gaudemar-Yamamoto models of the transition state.