Mechanisms of chromosome-end protection
Mechanisms of chromosome-end protection
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DOI：
10.1016/s0955-0674(02)00325-3
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发表时间：
2002-06-01
影响因子：
7.5
通讯作者：
Lundblad, V
中科院分区：
文献类型：
--
作者：
Cervantes, RB;Lundblad, V
端粒必须保护染色体末端不被识别和处理为双链断裂。识别参与末端保护的因子，以及它们为染色体末端“加盖”的机制，对于理解细胞如何区分双链断裂和正常端粒末端至关重要。最近的工作特点的相似性和潜在的差异，利用多种生物体在维持端粒末端的途径。一个统一的概念，已经清楚地出现的是，染色体末端保护是必要的，在保持遗传稳定性和防止肿瘤发生。
Telomeres must protect chromosome ends from being recognized and processed as double-strand breaks. Identification of the factors involved in end protection, and the mechanisms by which they 'cap' chromosome termini, is crucial in understanding how the cell distinguishes between a double-strand break and a normal telomere end. Recent work has characterized the similarities and potential differences between the pathways utilized by multiple organisms in maintaining telomere ends. One unifying concept that has clearly emerged is that chromosome-end protection is necessary in maintaining genetic stability and preventing oncogenesis.