Homeobrain, a novel paired-like homeobox gene is expressed in the Drosophila brain
Homeobrain, a novel paired-like homeobox gene is expressed in the Drosophila brain
复制标题
Homeobrain，一种新型的配对样同源框基因，在果蝇大脑中表达
DOI：
10.1016/s0925-4773(00)00380-4
复制
发表时间：
2000
影响因子：
2.6
通讯作者：
William McGinnis
中科院分区：
文献类型：
--
作者：
U. Walldorf;Andrea Kiewe;Melanie Wickert;Matthew Ronshaugen;William McGinnis
同源盒基因(Homeobrain，hBN)是一种新的成对同源框基因，在胚胎脑和腹神经索中表达。同源基因的表达始于胚胎期的前背部头部原基，并在这些细胞中持续表达，这些细胞在胚胎后期形成大脑的一部分。从第11阶段开始，在腹神经索的细胞中检测到另一种较弱的表达模式。Homeobrain蛋白中的同源结构域与果蝇蛋白DRx、Aristaless和Munster最相似。此外，Homeobrain和DRx的局部脑表达模式彼此相似。另外两个同源异型盒基因，Oropedia和DRx与同源异型盒一起聚集在57B区域。目前的证据表明，同源盒、DRx和正畸形成了一个同源盒基因簇，其中所有成员都在特定的胚胎脑亚区表达。
The homeobrain(hbn) gene is a new paired-like homeobox gene which is expressed in the embryonic brain and the ventral nerve cord. Expression of homeobrain initiates during the blastoderm stage in the anterior dorsal head primordia and the gene is persistently expressed in these cells which form parts of the brain during later embryonic stages. An additional weaker expression pattern is detected in cells of the ventral nerve cord from stage 11 on. The homeodomain in the Homeobrain protein is most similar to the Drosophila proteins DRx, Aristaless and Munster. In addition, the localized brain expression patterns of homeobrain and DRx resemble each other. Two other homeobox genes, orthopedia and DRx are clustered in the 57B region along with homeobrain. The current evidence indicates that homeobrain, DRx and orthopedia form a homeobox gene cluster in which all the members are expressed in specific embryonic brain subregions.
影响因子：
4.6
作者：
Sheryl T. Smith;J. B. Jaynes
通讯作者：
Sheryl T. Smith;J. B. Jaynes