Gold Nanoparticles for Modulating Neuronal Behavior.
Gold Nanoparticles for Modulating Neuronal Behavior.
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DOI：
10.3390/nano7040092
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发表时间：
2017-04-24
期刊：
影响因子：
--
通讯作者：
Stoddart PR
中科院分区：
文献类型：
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作者：
Paviolo C;Stoddart PR
了解大脑和神经系统的详细功能和病理生理学仍然是科学界面临的挑战，特别是在监控和与复杂3D网络连接的扩展技术方面。纳米技术有可能支持这种规模的扩大，最终目标是解决中枢和外周神经系统功能单位内的单个神经细胞。金纳米粒子提供了各种物理和化学性质，作为光激活的纳米级神经元界面引起了人们的注意。本文综述了化学功能化金纳米粒子的光热和光机械特性，这些特性已被用于触发神经元组织中的一系列生物反应，包括电活动和神经再生的调制。最后讨论了进一步发展的前景和挑战。
Understanding the detailed functioning and pathophysiology of the brain and the nervous system continues to challenge the scientific community, particularly in terms of scaling up techniques for monitoring and interfacing with complex 3D networks. Nanotechnology has the potential to support this scaling up, where the eventual goal would be to address individual nerve cells within functional units of both the central and peripheral nervous system. Gold nanoparticles provide a variety of physical and chemical properties that have attracted attention as a light-activated nanoscale neuronal interface. This review provides a critical overview of the photothermal and photomechanical properties of chemically functionalized gold nanoparticles that have been exploited to trigger a range of biological responses in neuronal tissues, including modulation of electrical activity and nerve regeneration. The prospects and challenges for further development are also discussed.