Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell
Killer T cells regulate antigen presentation for early expansion of memory, but not naive, CD8+ T cell
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DOI：
10.1073/pnas.0609990104
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发表时间：
2007-04-10
影响因子：
11.1
通讯作者：
Davenport, Miles P.
中科院分区：
文献类型：
--
作者：
Belz, Gabrielle T.;Zhang, Lei;Davenport, Miles P.
引流感染部位的淋巴结内的抗原呈递对于细胞毒性T细胞应答的启动至关重要。这种抗原呈递是如何精确地调节体内T细胞扩增的还不清楚。在这里，我们表明，在初次感染中，抗原呈递在感染后约3天达到高峰，然后缓慢衰减，直到第12天。这种延长的抗原呈递对于初始CD8（+）T细胞的最佳扩增是必需的，因为早期清除克伦特氏细胞减少了后来的CD8（+）T细胞应答。抗原呈递在继发感染的幅度低10倍，并在感染后第4天基本上终止。抗原特异性T细胞的记忆性（而非初始）扩增受到抗原呈递细胞的穿孔素依赖性细胞溶解的严格控制。记忆T细胞去除抗原呈递细胞的能力提供了一个负反馈回路，以直接限制体内抗原呈递的持续时间。
Antigen presentation within the lymph node draining a site of infection is crucial for initiation of cytotoxic T cell responses. Precisely how this antigen presentation regulates T cell expansion in vivo is unclear. Here, we show that, in primary infection, antigen presentation peaks -3 days postinfection and then slowly decays until day 12. This prolonged antigen presentation is required for optimal expansion of naive CD8(+) T cells, because early ablation of clendritic cells reduces the later CD8(+) T cell response. Antigen presentation during secondary infection was 10-fold lower in magnitude and largely terminated by day 4 postinfection. Expansion of memory, but not naive, antigen-specific T cells was tightly controlled by perforin-dependent cytolysis of antigen-presenting cells. The ability of the memory T cells to remove antigenpresenting cells provides a negative-feed back loop to directly limit the duration of antigen presentation in vivo.