A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells
A water-soluble iron-porphyrin complex capable of rescuing CO-poisoned red blood cells
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DOI：
10.1039/d1cc05542a
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发表时间：
2022-01-28
影响因子：
4.9
通讯作者：
Johnstone, Timothy C.
中科院分区：
文献类型：
--
作者：
Droege, Daniel G.;Johnstone, Timothy C.
我们在此描述了一种小分子平台，其表现出CO中毒解毒剂所需的关键特性。该设计的特点是在大环平面上方和下方具有大体积取代基的铁卟啉络合物，以提供用于CO结合的疏水口袋，并防止形成无活性的氧代桥接二聚体。外围带电基团赋予水溶性。我们证明，铁（II）配合物的卟啉与2，6-二苯基-4-磺基苯内消旋取代基可以结合CO，化学计量螯合CO从碳氧血红蛋白，和救援CO中毒的红细胞。
We describe herein a small-molecule platform that exhibits key properties needed by an antidote for CO poisoning. The design features an iron-porphyrin complex with bulky substituents above and below the macrocyclic plane to provide a hydrophobic pocket for CO binding and to prevent the formation of inactive oxo-bridged dimers. Peripheral charged groups impart water solubility. We demonstrate that the Fe(ii) complex of a porphyrin with 2,6-diphenyl-4-sulfophenyl meso substituents can bind CO, stoichiometrically sequester CO from carboxyhemoglobin, and rescue CO-poisoned red blood cells.