Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis.
Associations between dopamine D2 receptor gene polymorphisms and schizophrenia risk: a PRISMA compliant meta-analysis.
复制标题
多巴胺 D2 受体基因多态性与精神分裂症风险之间的关联：符合 PRISMA 的荟萃分析
DOI：
10.2147/ndt.s118614
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发表时间：
2016
影响因子：
3.2
通讯作者：
Ma X
中科院分区：
文献类型：
--
作者：
He H;Wu H;Yang L;Gao F;Fan Y;Feng J;Ma X
目的通过荟萃分析，探讨多巴胺D2受体基因多态性与精神分裂症发病风险的关系。方法检索PubMed、Embase和中国知识基础设施数据库，检索截至2016年2月已发表的相关文献。采用等位基因对比模型。采用Stata软件进行统计分析，计算比值比（ORs）和95%置信区间（CIs），评估多巴胺D2受体基因多态性与精神分裂症风险之间的关系。还进行了meta回归和发表偏倚、修整和填充、亚组、敏感性、累积和故障安全数分析。结果本荟萃分析包括81项研究。rs1801028和rs1799732与亚洲人的精神分裂症风险相关（P=0.04， OR= 1.25, 95% CI = 1.01-1.55； P<0.01， OR= 0.76, 95% CI = 0.63-0.92），而rs6277与高加索人的精神分裂症风险相关（P<0.01， OR=0.72, 95% CI = 0.66-0.79）。在以人群为基础的对照中，rs1800497也与精神分裂症风险相关（P<0.01, OR =0.84, 95% CI = 0.72-0.97）。rs6275、rs1079597和rs1800498与精神分裂症风险无关。此外，meta回归表明，对照可能是rs1801028单核苷酸多态性（SNP）的异质性来源，而种族可能是rs6277 SNP的异质性来源。rs1801028 SNP的发表偏倚显著，采用补齐法调整发表偏倚后结果发生改变。结论本荟萃分析表明rs1801028可能是亚洲人精神分裂症易感性的危险因素，而rs1799732可能是该人群的保护因素。大样本研究是验证这一荟萃分析结果的必要条件。
Objective To determine the relationships between dopamine D2 receptor gene polymorphisms and the risk of schizophrenia using meta-analysis. Method The PubMed, Embase, and China National Knowledge Infrastructure databases were searched to identify relevant literature published up to February 2016. The allele contrast model was used. Stata software was used for statistical analysis, with odds ratios (ORs) and 95% confidence intervals (CIs) calculated to evaluate the associations between dopamine D2 receptor gene polymorphisms and the risk of schizophrenia. Meta-regression and publication bias, trim-and-fill, subgroup, sensitivity, cumulative, and fail-safe number analyses were also performed. Results This meta-analysis included 81 studies. The rs1801028 and rs1799732 were associated with schizophrenia risk among Asians (P=0.04, OR =1.25, 95% CI =1.01–1.55; P<0.01, OR =0.76, 95% CI =0.63–0.92, respectively), while the rs6277 was associated with schizophrenia risk in Caucasians (P<0.01, OR=0.72, 95% CI =0.66–0.79). The rs1800497 was also associated with schizophrenia risk in population-based controls (P<0.01, OR =0.84, 95% CI =0.72–0.97). The rs6275, rs1079597, and rs1800498 were not associated with schizophrenia risk. In addition, meta-regression indicated that the controls may be sources of heterogeneity for the rs1801028 single-nucleotide polymorphism (SNP), while ethnicity may be sources of heterogeneity for the rs6277 SNP. Publication bias was significant for the rs1801028 SNP, and this result changed after the publication bias was adjusted using the trim-and-fill method. Conclusion This meta-analysis demonstrated that the rs1801028 may be a risk factor for susceptibility to schizophrenia among Asians, while the rs1799732 may be a protective factor for that population. Large-sample studies are necessary to verify the results of this meta-analysis.