Effect of Phone Text Message Reminders on Compliance with Rabies Post-Exposure Prophylaxis following Dog Bites in Rural Kenya.

Effect of Phone Text Message Reminders on Compliance with Rabies Post-Exposure Prophylaxis following Dog Bites in Rural Kenya.
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DOI:
10.3390/vaccines11061112
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发表时间:
2023-06-18
期刊:
影响因子:
7.8
通讯作者:
Thumbi SM
Thumbi SM
中科院分区:
医学3区
文献类型:
--
作者:
Chuchu VM;Mutono N;Bichanga P;Kitala PM;Ksee D;Muturi M;Mwatondo A;Nasimiyu C;Akunga L;Amiche A;Hampson K;Thumbi SM

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及时进行暴露后预防(PEP)是终止狂犬病导致人类死亡的关键策略之一。延迟寻求狂犬病PEP的第一剂,或未能完成推荐剂量,可能导致临床狂犬病和死亡。我们评估了短消息系统(SMS)电话短信在改善肯尼亚东部农村咬伤患者对预定PEP剂量的依从性方面的疗效。我们进行了一项单臂,前后现场试验,比较了2018年10月至12月(对照)和2019年1月至3月(干预)期间在马奎尼转诊医院就诊的咬伤患者的依从性。他们的人口统计数据,社会经济地位,周围的情况下咬,和相关的开支咬收集。共有186名咬伤患者入组,其中干预组82名(44%),对照组104名(56%)。与对照组相比,接受短信提醒的患者完成PEP的几率高出3倍(OR 3.37,95% CI 1.28,10.20)。干预组对预定剂量2至5的依从性更好,平均偏差为0.18天,而对照组为0.79天(p = 0.004)。不遵守规定的主要原因包括缺乏资金(30%)和忘记(23%)后续治疗日等。几乎所有(96%,n = 179)咬伤患者都产生了间接交通费用,平均每次就诊4美元(0-45美元)。这项研究表明,将短信提醒整合到医疗服务提供中可以提高PEP的依从性,并可能加强狂犬病控制和消除策略。
The prompt administration of post-exposure prophylaxis (PEP) is one of the key strategies for ending human deaths from rabies. A delay in seeking the first dose of rabies PEP, or failure to complete the recommended dosage, may result in clinical rabies and death. We assessed the efficacy of short message system (SMS) phone texts in improving the adherence to scheduled PEP doses among bite patients in rural eastern Kenya. We conducted a single-arm, before-after field trial that compared adherence among bite patients presenting at Makueni Referral Hospital between October and December 2018 (control) and between January and March 2019 (intervention). Data on their demographics, socio-economic status, circumstances surrounding the bite, and expenditures related to the bite were collected. A total of 186 bite patients were enrolled, with 82 (44%) in the intervention group, and 104 (56%) in the control group. The odds of PEP completion were three times (OR 3.37, 95% CI 1.28, 10.20) more likely among patients who received the SMS reminder, compared to the control. The intervention group had better compliance on the scheduled doses 2 to 5, with a mean deviation of 0.18 days compared to 0.79 days for the control group (p = 0.004). The main reasons for non-compliance included lack of funds (30%), and forgetfulness (23%) on days for follow-up treatment, among others. Nearly all (96%, n = 179) the bite patients incurred indirect transport costs, at an average of USD 4 (USD 0–45) per visit. This study suggests that the integration of SMS reminders into healthcare service delivery increases compliance with PEP, and may strengthen rabies control and elimination strategies.
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