The dual role of calcium as messenger and stressor in cell damage, death, and survival.
The dual role of calcium as messenger and stressor in cell damage, death, and survival.
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DOI：
10.1155/2010/546163
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发表时间：
2010
影响因子：
--
通讯作者：
Ghibelli L
中科院分区：
文献类型：
--
作者：
Cerella C;Diederich M;Ghibelli L
Ca2+是参与许多细胞活动的重要第二信使；当物理化学损伤破坏其微妙的稳态时，它会充当内在的应激源，产生/增加细胞损伤。损伤会引发修复和死亡反应；有趣的是，Ca2+ 也作为第二信使参与这些反应。这描绘了 Ca2+ 在细胞应激中的双重作用，使得难以区分 Ca2+ 介导的细胞存活和凋亡控制所需的不同和多种机制。在这里，我们试图理清这两种情况，一方面检查与放松管制的 Ca2+ 毒性有关的事件以及由此引发修复或死亡途径的机制；另一方面，回顾了 Ca2+ 作为信使在这些相同信号事件转导中的作用。
Ca2+ is an important second messenger participating in many cellular activities; when physicochemical insults deregulate its delicate homeostasis, it acts as an intrinsic stressor, producing/increasing cell damage. Damage elicits both repair and death responses; intriguingly, in those responses Ca2+ also participates as second messenger. This delineates a dual role for Ca2+ in cell stress, making difficult to separate the different and multiple mechanisms required for Ca2+-mediated control of cell survival and apoptosis. Here we attempt to disentangle the two scenarios, examining on the one side, the events implicated in deregulated Ca2+ toxicity and the mechanisms through which this elicits reparative or death pathways; on the other, reviewing the role of Ca2+ as a messenger in the transduction of these same signaling events.