Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia
Functional dissociation between anterior temporal lobe and inferior frontal gyrus in the processing of dynamic body expressions: Insights from behavioral variant frontotemporal dementia
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DOI：
10.1002/hbm.23322
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发表时间：
2016-12-01
影响因子：
4.8
通讯作者：
Vandenbulcke, Mathieu
中科院分区：
文献类型：
--
作者：
Jastorff, Jan;De Winter, Francois-Laurent;Vandenbulcke, Mathieu
几个大脑区域参与情绪刺激的处理，然而，特定区域对情绪感知的贡献仍然存在争议。为了研究这一问题，我们对被诊断为行为变异性额颞叶痴呆（bvFTD）的患者和年龄匹配的对照组进行了行为测试、结构和静息状态成像，并对年轻健康志愿者进行了基于任务的功能成像。正如预期的那样，bvFTD患者在情绪检测和情绪分类任务中受损，测试动态情绪体表达作为刺激。有趣的是，他们在这两项任务中的表现与大脑中两个不同区域的灰质体积有关，即负责情绪检测的左前颞叶和负责情绪分类的左额下回。健康志愿者的多体素模式分析证实了这一观察结果，表明两种roi都包含用于情绪检测的信息，但情绪分类只能通过IFG中的模式进行。此外，功能连通性分析显示，bvFTD患者两个区域之间的连通性降低。研究结果表明，在情绪加工过程中，心智化网络和行动观察网络执行不同的任务。在bvFTD中，网络之间的通信减少，这表明行为症状背后的一个可能原因。中国生物医学工程学报（英文版），2016。(c) 2016 Wiley Periodicals, Inc.；
Several brain regions are involved in the processing of emotional stimuli, however, the contribution of specific regions to emotion perception is still under debate. To investigate this issue, we combined behavioral testing, structural and resting state imaging in patients diagnosed with behavioral variant frontotemporal dementia (bvFTD) and age matched controls, with task-based functional imaging in young, healthy volunteers. As expected, bvFTD patients were impaired in emotion detection as well as emotion categorization tasks, testing dynamic emotional body expressions as stimuli. Interestingly, their performance in the two tasks correlated with gray matter volume in two distinct brain regions, the left anterior temporal lobe for emotion detection and the left inferior frontal gyrus (IFG) for emotion categorization. Confirming this observation, multivoxel pattern analysis in healthy volunteers demonstrated that both ROIs contained information for emotion detection, but that emotion categorization was only possible from the pattern in the IFG. Furthermore, functional connectivity analysis showed reduced connectivity between the two regions in bvFTD patients. Our results illustrate that the mentalizing network and the action observation network perform distinct tasks during emotion processing. In bvFTD, communication between the networks is reduced, indicating one possible cause underlying the behavioral symptoms. Hum Brain Mapp 37:4472-4486, 2016. (c) 2016 Wiley Periodicals, Inc.