Neurodevelopment of very low birth weight infants in the first two years of life in a Havana tertiary care hospital.
Neurodevelopment of very low birth weight infants in the first two years of life in a Havana tertiary care hospital.
复制标题
DOI：
10.37757/mr2015.v17.n1.4
复制
发表时间：
2015
期刊：
影响因子：
2.1
通讯作者：
Gianny Cejas;Y. Gómez;María del Carmen Roca;F. Domínguez
中科院分区：
文献类型：
--
作者：
Gianny Cejas;Y. Gómez;María del Carmen Roca;F. Domínguez
引言
极低出生体重（<1500克）新生儿存活率的提高导致神经发育后遗症的发生率上升。
目的
在哈瓦那一家三级医院，研究出生体重<1500克的婴儿在出生后头两年的神经发育结果，并分析其与出生体重、胎龄以及1分钟和5分钟阿普加评分的关系。
方法
进行了一项病例系列研究，以评估极低出生体重婴儿在出生后头两年的神经发育结果。研究人群包括2006 - 2010年在古巴哈瓦那的拉蒙·冈萨雷斯·科罗大学妇产医院出生的116名极低出生体重（<1500克）的存活新生儿。对所有婴儿从出院到两岁（根据出生胎龄校正）进行了纵向、多学科和跨学科的神经发育随访。收集了每个婴儿的围产期变量数据：出生体重（克）、出生胎龄以及1分钟和5分钟阿普加评分。将患者分为神经发育正常、轻度异常和中重度异常。采用皮尔逊卡方检验来确定所研究的围产期变量与神经发育之间可能存在的关系，精确抽样分布且置信水平为95%。
结果
69%的极低出生体重婴儿神经发育正常，25.9%有轻度异常，5.2%有中重度异常。结果表明胎龄与神经发育结果之间存在统计学上的显著关系；在胎龄更小（<30周）出生的婴儿中发现更多的神经发育异常。
结论
出生胎龄较低的极低出生体重存活新生儿面临更高的神经发育异常风险。
INTRODUCTION Improved survival rates of neonates with very low birth weight (<1500 g) have led to a higher incidence of neurodevelopmental sequelae. OBJECTIVE Examine neurodevelopment outcomes over the first two years of life of infants who weighed <1500 g at birth, in relation to birth weight, gestational age and 1-minute and 5-minute Apgar scores, in a Havana tertiary care hospital. METHODS A case-series study was conducted to assess neurodevelopment outcomes of very low birth weight infants over their first two years of life. The study population comprised 116 surviving neonates with very low birth weight (<1500 g), born in the Dr Ramón González Coro University Maternity Hospital in Havana, Cuba, 2006-2010. A longitudinal, multidisciplinary and interdisciplinary follow up of all infants' neurodevelopment was performed, from hospital discharge to age two years, corrected for gestational age at birth. Data on each infant's perinatal variables were collected: birth weight in grams, gestational age at birth, and 1-minute and 5-minute Apgar scores. Patients were classified as having normal neurodevelopment, mild abnormalities and moderate-to-severe abnormalities. Pearson's chi-square test was used to determine possible relationships between perinatal variables studied and neurodevelopment, with exact sampling distribution and 95% confidence level. RESULTS Normal neurodevelopment was observed in 69% of very low birth weight infants, 25.9% had mild abnormalities, and 5.2% displayed moderate-to-severe abnormalities. The results demonstrate a statistically significant relationship between gestational age and neurodevelopmental outcomes; more neurodevelopmental abnormalities were found in infants born at earlier gestational age (<30 weeks). CONCLUSIONS Surviving very low birth weight neonates with lower gestational age at birth face a higher risk of neurodevelopmental abnormalities.